EFNBs bind SFKs

Stable Identifier
R-HSA-3928615
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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EFNBs bind SFKs
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Src-family kinases (SFKs) are required for ephrinB (EFNB)-mediated axon guidance and angiogenic responses in endothelial cells. Following interaction with their cognate EPHB receptors and formation of circular tetramers and higher order clusters, EFNBs recruit SFKs and become tyrosine phosphorylated on the cytoplasmic tail. SFK recruitment and activation represents one of the first events in EFNB reverse signaling (Palmer et al. 2002).
Literature References
PubMed ID Title Journal Year
11983165 EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase

Palmer, A, Zimmer, M, Erdmann, KS, Eulenburg, V, Porthin, A, Heumann, R, Deutsch, U, Klein, R

Mol. Cell 2002
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Orthologous Events
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Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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