EFNB:GRB4 binds GIT1

Stable Identifier
R-HSA-3928614
Type
Reaction [binding]
Species
Homo sapiens
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G-protein-coupled receptor kinase-interacting protein 1 (GIT1) is enriched in both presynaptic and postsynaptic terminals and after phosphorylation is targeted to the synapse by binding to cytoplasmic protein GRB4 (NCK2 aka GRB4). GRB4 binds by its SH2 domain to Tyr392 (Human Tyr383) in the synaptic localization domain (SLD) of GIT1. GIT1 acts as an adapter protein by providing docking site for beta-PIX (PAK interacting exchange factor) and serves to localize Rac activity (Segura et al. 2007, Zhang et al. 2003).

Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Zhang, H, Webb, DJ, Asmussen, H, Horwitz, AF

J. Cell Biol. 2003
17310244 Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

Segura, I, Essmann, CL, Weinges, S, Acker-Palmer, A

Nat. Neurosci. 2007
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