KALRN exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-3928612
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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KALRN exchanges GTP for GDP on RAC1, activating it
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The Dbl homology (DH) and pleckstrin homology (PH) domains of kalirin (KALRN) provides the GEF activity and is activated upon binding to EPHB. Activated KALRN with its GEF domains activates RAC1, and controls spine remodelling by modulating actin cytoskeletal rearrangements (Penzes & Jones 2008, Penzes et al. 2003).

Literature References
PubMed ID Title Journal Year
12546821 Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

Penzes, P, Eipper, BA, Schiller, MR, Huganir, RL, Chernoff, J, Beeser, A, Mains, RE

Neuron 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:KALRN [plasma membrane]

Physical Entity
EFNBs:p-EPHBs:KALRN [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
KALRN exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
KALRN exchanges GTP for GDP on RAC1, activating it (Danio rerio)
KALRN exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
KALRN exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)
KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
KALRN exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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