KALRN exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-3928612
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The Dbl homology (DH) and pleckstrin homology (PH) domains of kalirin (KALRN) provides the GEF activity and is activated upon binding to EPHB. Activated KALRN with its GEF domains activates RAC1, and controls spine remodelling by modulating actin cytoskeletal rearrangements (Penzes & Jones 2008, Penzes et al. 2003).

Literature References
PubMed ID Title Journal Year
12546821 Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

Penzes, P, Beeser, A, Chernoff, J, Schiller, MR, Eipper, BA, Mains, RE, Huganir, RL

Neuron 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:KALRN [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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