The Dbl homology (DH) and pleckstrin homology (PH) domains of kalirin (KALRN) provides the GEF activity and is activated upon binding to EPHB. Activated KALRN with its GEF domains activates RAC1, and controls spine remodelling by modulating actin cytoskeletal rearrangements (Penzes & Jones 2008, Penzes et al. 2003).
Penzes, P, Eipper, BA, Schiller, MR, Huganir, RL, Chernoff, J, Beeser, A, Mains, RE
guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:KALRN [plasma membrane]
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