Recruitment of p190RhoGEF to p-FAK

Stable Identifier
Reaction [binding]
Homo sapiens
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FAK-mediated spine morphogenesis was shown to occur, in part through Rho guanine nucleotide exchange factor 28 (ARHGEF28, p190RhoGEF), suggesting that FAK-mediated spine maturation might proceed through a FAK-RhoGEF-RHOA mechanism. p190RhoGEF binds directly to phosphorylated PTK2 through a motif in the RhoGEF C-terminal domain, a feature not shared with other GEFs (Moeller et al. 2006, Rico et al. 2004, Zhai et al. 2003).

Literature References
PubMed ID Title Journal Year
12702722 Direct interaction of focal adhesion kinase with p190RhoGEF

Schlaepfer, WW, CaƱete-Soler, R, Nie, Z, Wu, J, Zhai, J, Lin, H, Schlaepfer, DD

J. Biol. Chem. 2003
16298995 EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation

Moeller, ML, Reichardt, LF, Shi, Y, Ethell, IM

J. Biol. Chem. 2006
15378065 Control of axonal branching and synapse formation by focal adhesion kinase

Schmidt, A, Beggs, HE, Reichardt, LF, Schahin-Reed, D, Kimes, N, Rico, B

Nat. Neurosci. 2004
Orthologous Events
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