Recruitment of p190RhoGEF to p-FAK

Stable Identifier
R-HSA-3928598
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

FAK-mediated spine morphogenesis was shown to occur, in part through Rho guanine nucleotide exchange factor 28 (ARHGEF28, p190RhoGEF), suggesting that FAK-mediated spine maturation might proceed through a FAK-RhoGEF-RHOA mechanism. p190RhoGEF binds directly to phosphorylated PTK2 through a motif in the RhoGEF C-terminal domain, a feature not shared with other GEFs (Moeller et al. 2006, Rico et al. 2004, Zhai et al. 2003).

Literature References
PubMed ID Title Journal Year
16298995 EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation

Moeller, ML, Shi, Y, Reichardt, LF, Ethell, IM

J. Biol. Chem. 2006
12702722 Direct interaction of focal adhesion kinase with p190RhoGEF

Zhai, J, Lin, H, Nie, Z, Wu, J, CaƱete-Soler, R, Schlaepfer, WW, Schlaepfer, DD

J. Biol. Chem. 2003
15378065 Control of axonal branching and synapse formation by focal adhesion kinase

Rico, B, Beggs, HE, Schahin-Reed, D, Kimes, N, Schmidt, A, Reichardt, LF

Nat. Neurosci. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created