EPH:EFN dimers tetramerise

Stable Identifier
R-HSA-3928597
Type
Reaction [transition]
Species
Homo sapiens
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Two class A or B EPH:EFN complexes dimerise to form a 2:2 tetramer, forming a ring-like structure, in which each receptor interacts with two ligands and each ligand with two receptors (Himanen et al. 2001). In the tetrameric form the molecules are arranged so that the C-termini of both ligands are located on one side, and the C-termini of the receptors on the other (Himanen & Nikolov 2003).

Literature References
PubMed ID Title Journal Year
11780069 Crystal structure of an Eph receptor-ephrin complex

Himanen, JP, Rajashankar, KR, Lackmann, M, Cowan, CA, Henkemeyer, M, Nikolov, DB

Nature 2001
12495863 Eph signaling: a structural view

Himanen, JP, Nikolov, DB

Trends Neurosci. 2003
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