N-WASP binds ARP2/3 and G-actin

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once neural Wiskott-Aldrich syndrome protein (WASL, N-WASP) is activated its VCA region becomes available for binding to actin-related protein (ARP2/3) complex and actin monomer. The actin monomer binds to the V-domain and ARP2/3 complex binds to the CA-domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of ARP2/3-complex-mediated actin polymerization (Takenawa & Suetsugu 2007). Actin polymerisation via N-WASP and the ARP2/3 complex leads to spherical expansion of dendritic spine heads.

Literature References
PubMed ID Title Journal Year
11747816 Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities

Zalevsky, J, Lempert, L, Kranitz, H, Mullins, RD

Curr Biol 2001
10219243 The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

Rohatgi, R, Ma, L, Miki, H, Lopez, M, Kirchhausen, Tomas, Takenawa, T, Kirschner, MW

Cell 1999
Participant Of
Orthologous Events
Cite Us!