N-WASP binds ARP2/3 and G-actin

Stable Identifier
R-HSA-3928595
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Once neural Wiskott-Aldrich syndrome protein (WASL, N-WASP) is activated its VCA region becomes available for binding to actin-related protein (ARP2/3) complex and actin monomer. The actin monomer binds to the V-domain and ARP2/3 complex binds to the CA-domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of ARP2/3-complex-mediated actin polymerization (Takenawa & Suetsugu 2007). Actin polymerisation via N-WASP and the ARP2/3 complex leads to spherical expansion of dendritic spine heads.

Literature References
PubMed ID Title Journal Year
11747816 Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities

Zalevsky, J, Lempert, L, Kranitz, H, Mullins, RD

Curr Biol 2001
10219243 The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

Rohatgi, R, Ma, L, Miki, H, Lopez, M, Kirchhausen, Tomas, Takenawa, T, Kirschner, MW

Cell 1999
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