p190RhoGEF exchanges GTP for GDP on RHOA, activating it

Stable Identifier
R-HSA-3928592
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Receptor stimulation induces translocation of RHOA from the cytosol to the plasma membrane and subsequent activation of RHOA. Rho guanine nucleotide exchange factor 28 (p190RhoGEF, ARHGEF28) is a specific activator of RHOA that stimulates the exchange of GDP for GTP. In neuronal cells p190RhoGEF binds to and activates RHOA with its Dbl homology/pleckstrin homology domain (van Horck et al. 2001).

Literature References
PubMed ID Title Journal Year
11058585 Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules

van Horck, FP, Ahmadian, MR, Haeusler, LC, Moolenaar, WH, Kranenburg, O

J. Biol. Chem. 2001
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane]

Orthologous Events
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