Reactome | EPH:EFN tetramers oligomerise

EPH:EFN tetramers oligomerise

Stable Identifier

R-HSA-3928591

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The effective activation of the EPH kinase domain requires oligomerisation of EPH receptors and ephrins (EFNs) (Davis et al. 1994). Tetrameric EPH:EFN complexes aggregate into higher-ordered EPH:EFN clusters through several low-affinity EPH:EPH and EFN:EFN interactions, which may be responsible for EPH:EFN signaling (Stein et al. 1998, Pabbisetty et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17322526	Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay Yue, X, Zhou, R, Himanen, JP, Nikolov, DB, Pabbisetty, KB, Li, C, Hu, L	Protein Sci.	2007
9499402	Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses Lane, AA, Schroff, AD, Schoecklmann, HO, Van Etten, RL, Cerretti, DP, Stein, E, Daniel, TO	Genes Dev.	1998