EPH:EFN tetramers oligomerise

Stable Identifier
R-HSA-3928591
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The effective activation of the EPH kinase domain requires oligomerisation of EPH receptors and ephrins (EFNs) (Davis et al. 1994). Tetrameric EPH:EFN complexes aggregate into higher-ordered EPH:EFN clusters through several low-affinity EPH:EPH and EFN:EFN interactions, which may be responsible for EPH:EFN signaling (Stein et al. 1998, Pabbisetty et al. 2007).

Literature References
PubMed ID Title Journal Year
9499402 Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

Stein, E, Lane, AA, Cerretti, DP, Schoecklmann, HO, Schroff, AD, Van Etten, RL, Daniel, TO

Genes Dev. 1998
17322526 Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay

Pabbisetty, KB, Yue, X, Li, C, Himanen, JP, Zhou, R, Nikolov, DB, Hu, L

Protein Sci. 2007
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