Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EPHB3 (?-998) [plasma membrane]
Stable Identifier
R-HSA-3928413
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-B receptor 3 ecNumber2.7.10.1/ecNumber, EPHB3_HUMAN, EPHB3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
MMP2,9 cleave EPHB (Homo sapiens)
EPHB C-terminal fragments (CTF) [plasma membrane] (Homo sapiens)
EPHB3 (?-998) [plasma membrane] (Homo sapiens)
gamma-secretase cleaves EPHB2 (Homo sapiens)
EPHB C-terminal fragments (CTF) [plasma membrane] (Homo sapiens)
EPHB3 (?-998) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54753 EPHB3
Gene Names
EPHB3, ETK2, HEK2, TYRO6
Chain
signal peptide:1-33, chain:34-998
Reference Genes
BioGPS Gene:2049 EPHB3
COSMIC (genes):EPHB3 EPHB3
CTD Gene:2049 EPHB3
dbSNP Gene:2049 EPHB3
ENSEMBL:ENSG00000182580 EPHB3
HGNC:3394 EPHB3
KEGG:hsa:2049 EPHB3
Monarch:2049 EPHB3
NCBI Gene:2049 EPHB3
OMIM:601839 EPHB3
UCSC:P54753 EPHB3
Reference Transcript
RefSeq:NM_004443.3 EPHB3
Other Identifiers
11724421_at
1438_PM_at
1438_at
16949062
204600_PM_at
204600_at
2049
2655876
2655877
2655880
2655883
2655884
2655890
2655892
2655893
2655894
2655895
2655896
2655897
2655898
2655899
2655900
2655901
2655902
2655903
2655904
2655905
2655906
2655907
2655908
2655909
2655910
2655912
8084524
A_14_P130352
A_14_P202445
A_23_P95060
GE59998
GO:0001525
GO:0001655
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005005
GO:0005515
GO:0005524
GO:0005576
GO:0005829
GO:0005886
GO:0006468
GO:0007155
GO:0007169
GO:0007399
GO:0007411
GO:0007413
GO:0008046
GO:0016020
GO:0016477
GO:0016740
GO:0021952
GO:0022038
GO:0022407
GO:0030425
GO:0031290
GO:0034446
GO:0042995
GO:0043087
GO:0046777
GO:0048013
GO:0048538
GO:0048546
GO:0048856
GO:0048870
GO:0050770
GO:0051965
GO:0060021
GO:0060089
GO:0060996
GO:0060997
GO:0140096
ILMN_1741346
PH_hs_0000371
TC03001007.hg
X75208_at
X75208cds_3p_s_at
g4758287_3p_at
g4758287_3p_x_at
Participates
as a member of
EPHB C-terminal fragments (CTF) [plasma membrane] (Homo sapiens)
Other forms of this molecule
EPHB3 (?-?) [plasma membrane]
EPHB3 (?-998) [cytosol]
EPHB3 (34-?) [extracellular region]
EPHB3 [plasma membrane]
p-Y608,Y614-EPHB3 [plasma membrane]
Inferred To
EPHB3 (?-998) [plasma membrane]
(Bos taurus)
EPHB3 (?-998) [plasma membrane]
(Canis familiaris)
EPHB3 (?-998) [plasma membrane]
(Gallus gallus)
EPHB3 (?-998) [plasma membrane]
(Mus musculus)
EPHB3 (?-998) [plasma membrane]
(Sus scrofa)
EPHB3 (?-998) [plasma membrane]
(Xenopus tropicalis)
Ephb3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_004434.2
ZINC - World Drugs
EPHB3_HUMAN
Guide to Pharmacology - Targets
1832
ENSEMBL
ENST00000330394
,
ENSP00000332118
OpenTargets
ENSG00000182580
ZINC - FDA approved
EPHB3_HUMAN
ZINC - Substances
EPHB3_HUMAN
ZINC target
P54753
PRO
P54753
GlyGen
P54753
PDB
3ZFY
,
3P1I
,
5L6O
,
5L6P
ZINC - Investigational
EPHB3_HUMAN
IntEnz
2.7.10.1
HPA
ENSG00000182580-EPHB3
Pharos - Targets
P54753
ZINC - Predictions - Purchasable
EPHB3_HUMAN
HMDB Protein
HMDBP01507
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text