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p-Y650,Y656-EPHA5 [plasma membrane]
Stable Identifier
R-HSA-3928343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-A receptor 5 ecNumber2.7.10.1/ecNumber, EPHA5_HUMAN, EPHA5
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
p-EPHs bind VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
NGEF binds EPHA (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
SFKs phosphorylate NGEF (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
p-EPHAs [plasma membrane] (Homo sapiens)
p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54756 EPHA5
Gene Names
EPHA5, BSK, EHK1, HEK7, TYRO4
Chain
signal peptide:1-24, chain:25-1037
Reference Genes
BioGPS Gene:2044 EPHA5
COSMIC (genes):EPHA5 EPHA5
CTD Gene:2044 EPHA5
dbSNP Gene:2044 EPHA5
ENSEMBL:ENSG00000145242 EPHA5
ENSEMBL:ENSG00000145242.14 EPHA5
HGNC:3389 EPHA5
KEGG Gene (Homo sapiens):2044 EPHA5
Monarch:2044 EPHA5
NCBI Gene:2044 EPHA5
OMIM:600004 EPHA5
UCSC:P54756 EPHA5
Reference Transcript
RefSeq:NM_182472.4 EPHA5
RefSeq:NM_001281766.2 EPHA5
RefSeq:NM_001318761.1 EPHA5
RefSeq:NM_001281765.2 EPHA5
RefSeq:NM_004439.7 EPHA5
Other Identifiers
11730142_a_at
11730143_a_at
1604_at
1605_g_at
16976329
2044
215664_PM_s_at
215664_s_at
237939_PM_at
237939_at
2771343
2771344
2771345
2771346
2771350
2771351
2771356
2771357
2771359
2771361
2771364
2771367
2771372
2771374
2771377
2771379
2771388
2771394
2771411
2771412
2771415
2771416
2771425
2771426
34564_at
8100578
88944_at
A_23_P147839
A_32_P149640
GE892980
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005004
GO:0005005
GO:0005515
GO:0005524
GO:0005783
GO:0005791
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007169
GO:0007399
GO:0007411
GO:0009897
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019933
GO:0021766
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0032793
GO:0032956
GO:0036211
GO:0042995
GO:0043025
GO:0043087
GO:0043226
GO:0048013
GO:0048471
GO:0048666
GO:0048856
GO:0060089
GO:0061178
GO:0140096
HMNXSV003044382
Hs.202436.0.A1_3p_at
Hs.31092.1.S1_3p_a_at
ILMN_1668022
ILMN_1767342
ILMN_2402874
L36644_at
PH_hs_0022996
TC04001245.hg
X95425_s_at
Participates
as a member of
p-EPHAs [plasma membrane] (Homo sapiens)
Other forms of this molecule
EPHA5 [plasma membrane]
Inferred To
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Bos taurus)
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Canis familiaris)
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Danio rerio)
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Gallus gallus)
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Rattus norvegicus)
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Sus scrofa)
phospho-p-Y650,Y656-EPHA5 [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 650
Coordinate
650
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 656
Coordinate
656
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001268695.1
,
NP_872272.2
,
NP_004430.4
,
NP_001305690.1
,
NP_001268694.1
ZINC - World Drugs
EPHA5_HUMAN
Guide to Pharmacology - Targets
1825
OpenTargets
ENSG00000145242
ZINC - FDA approved
EPHA5_HUMAN
ZINC - Substances
EPHA5_HUMAN
ZINC target
P54756
ZINC - Biogenic
EPHA5_HUMAN
PRO
P54756
PDB
4ET7
,
2R2P
ZINC - Investigational
EPHA5_HUMAN
HPA
ENSG00000145242-EPHA5
GeneCards
P54756
Ensembl
ENSP00000346899
,
ENSP00000273854
,
ENST00000273854
,
ENSG00000145242
,
ENST00000354839
Pharos - Targets
P54756
ZINC - Predictions - Purchasable
EPHA5_HUMAN
HMDB Protein
HMDBP01168
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