PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.
Condliffe, AM, Stephens, L, Ellson, CD, Hawkins, PT, Welch, H, Coadwell, J, Turner, M, Suire, S, Davidson, K, Ferguson, GJ, Chilvers, ER, Guillou, H
Hawkins, PT, Stephens, LR
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