Reactome | G beta:gamma signalling through PI3Kgamma

G beta:gamma signalling through PI3Kgamma

Stable Identifier

R-HSA-392451

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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G beta:gamma signalling through PI3Kgamma

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PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.

Literature References

PubMed ID	Title	Journal	Year
17041586	Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils Condliffe, AM, Stephens, L, Ellson, CD, Hawkins, PT, Welch, H, Coadwell, J, Turner, M, Suire, S, Davidson, K, Ferguson, GJ, Chilvers, ER, Guillou, H	Nat Cell Biol	2006
17916723	PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis Hawkins, PT, Stephens, LR	Science	2007