Reactome | AVP(20-28) binds AVPR2

AVP(20-28) binds AVPR2

Stable Identifier

R-HSA-392263

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Vasopressin-like receptors (Homo sapiens)
        
        AVP(20-28) binds AVPR2 (Homo sapiens)

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Arginine vasopressin receptor 2 (AVPR2) (Birnbaumer et al. 1992) is expressed in the kidneys and can bind the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985). This receptor uses the G protein alpha s subunit as its second messenger system.

Literature References

PubMed ID	Title	Journal	Year
1534149	Molecular cloning of the receptor for human antidiuretic hormone Birnbaumer, M, Seibold, A, Gilbert, S, Ishido, M, Barberis, C, Antaramian, A, Brabet, P, Rosenthal, W	Nature	1992
2991279	The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line Sausville, E, Carney, D, Battey, J	J Biol Chem	1985
4065330	Expression of the vasopressin and oxytocin genes in human hypothalami Mohr, E, Hillers, M, Ivell, R, Haulica, ID, Richter, D	FEBS Lett	1985