Reactome | GRIA4 [plasma membrane]

GRIA4 [plasma membrane]

Stable Identifier

R-HSA-392229

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

GluR4

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Synaptic adhesion-like molecules (Homo sapiens)
    - SALM2 associate with AMPA and NMDA receptors (Homo sapiens)
      - AMPA, NMDA receptors [plasma membrane] (Homo sapiens)
        
        Ca permeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR1 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Homo sapiens)
        
        AMPA, NMDA receptors [plasma membrane] (Homo sapiens)
        
        Ca permeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR1 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Activation of AMPA receptors (Homo sapiens)
        
        Activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Activation of Ca permeable AMPA receptors (Homo sapiens)
        
        Ca permeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
        
        Ca permeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR1 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Ca impermeable AMPA receptor ligand binding (Homo sapiens)
        
        Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Ca permeable AMPA receptor ligand binding (Homo sapiens)
        
        Ca permeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
        
        Ca permeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR1 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Ca permeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR1 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        Ca permeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR1 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
        
        Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)
        
        Ca impermeable AMPA receptors (with phospho GluR2 S880) [plasma membrane] (Homo sapiens)
        
        AMPA receptors (heteromers) with phopho GluR2 [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)
        
        Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
        
        AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
        
        GRIA3,GRIA4 [plasma membrane] (Homo sapiens)
        
        GRIA4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48058 GRIA4

Gene Names

GRIA4, GLUR4

Chain

signal peptide:1-20, chain:21-902

Reference Genes

BioGPS Gene:2893 GRIA4

COSMIC (genes):GRIA4 GRIA4

CTD Gene:2893 GRIA4

dbSNP Gene:2893 GRIA4

ENSEMBL:ENSG00000152578 GRIA4

HGNC:4574 GRIA4

KEGG Gene (Homo sapiens):2893 GRIA4

Monarch:2893 GRIA4

NCBI Gene:2893 GRIA4

OMIM:138246 GRIA4

UCSC:P48058 GRIA4

Reference Transcript

Other Identifiers

0003290603

11730475_a_at

11730562_a_at

16730706

208464_at

238663_x_at

2893

3347121

3347122

3347123

3347124

3347125

3347126

3347127

3347128

3347129

3347130

3347150

3347151

3347163

3347167

3347168

3347169

3347170

3347171

3347172

3347173

3347175

3347176

3347177

3347178

3347179

3347182

3347183

3347194

3347195

3347198

3347199

59753_r_at

73453_at

78372_at

7943530

A_14_P100193

A_23_P98369

A_33_P3217153

A_33_P3497352

GE535280

GO:0001540

GO:0003674

GO:0004970

GO:0004971

GO:0005216

GO:0005575

GO:0005576

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006811

GO:0007165

GO:0007215

GO:0008150

GO:0015276

GO:0016020

GO:0016021

GO:0022857

GO:0030054

GO:0030425

GO:0030666

GO:0031410

GO:0032281

GO:0032991

GO:0034220

GO:0035235

GO:0038023

GO:0042995

GO:0043025

GO:0043197

GO:0043226

GO:0045202

GO:0045211

GO:0055085

GO:1903561

GO:2000310

Hs.31677.0.S1_3p_at

Hs.31677.0.S1_3p_x_at

ILMN_1692094

ILMN_1863253

ILMN_2322100

PH_hs_0022305

PH_hs_0039840

TC11000968.hg

U16129_at

g4557630_3p_at

Participant Of

hasMember

GRIA3,GRIA4 [plasma membrane]

Other forms of this molecule

GRIA4 [endocytic vesicle membrane]

Inferred To

Gria4 [plasma membrane] (Mus musculus)

Gria4 [plasma membrane] (Rattus norvegicus)

gria4b [plasma membrane] (Danio rerio)

cpne7 [plasma membrane] (Xenopus tropicalis)

GluRIB [plasma membrane] (Drosophila melanogaster)

glr-2 [plasma membrane] (Caenorhabditis elegans)

GRIA4 [plasma membrane] (Canis familiaris)

GRIA4 [plasma membrane] (Gallus gallus)

GRIA4 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001070712.1, NP_000820.3, NP_001070711.2, NP_001106283.1, XP_006718886.1

OpenTargets

ENSG00000152578

GeneCards

P48058

HPA

ENSG00000152578-GRIA4

ZINC target

P48058

Ensembl

ENST00000393125, ENST00000428631, ENSG00000152578, ENSP00000282499, ENSP00000415551, ENST00000282499, ENSP00000376833, ENST00000530497, ENSP00000435775

PRO

P48058

Orphanet

28743

HMDB Protein

HMDBP12051

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