Gi activation by P2Y purinoceptor 12

Stable Identifier
R-HSA-392195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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The G-protein alpha subunit exchanges GDP for GTP

Literature References
PubMed ID Title Journal Year
8554519 The human platelet ADP receptor activates Gi2 proteins

Ohlmann, P, Laugwitz, KL, Nurnberg, B, Spicher, K, Schultz, G, Cazenave, JP, Gachet, C

Biochem J 1995
11196645 Identification of the platelet ADP receptor targeted by antithrombotic drugs

Hollopeter, G, Jantzen, HM, Vincent, D, Li, G, England, L, Ramakrishnan, V, Yang, RB, Nurden, P, Nurden, A, Julius, D, Conley, PB

Nature 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of ADP:P2RY12:G-protein Gi (inactive) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created