SOS binds Grb2 bound to pFAK:NCAM1

Stable Identifier
R-HSA-392053
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SOS binds Grb2 bound to pFAK:NCAM1
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Guanine nucleotide releasing factor Sos associates with FAK bound Grb2 to activate Ras and initiate Ras-MAPK signaling. This interaction occurs between the carboxy terminal domain of SOS and the Src homology 3 (SH3) domains of GRB2.
Literature References
PubMed ID Title Journal Year
12700044 Cellular signalling mechanisms of neural cell adhesion molecules

Panicker, AK, Thelen, K, Buhusi, M, Maness, PF

Front Biosci 2003
2809592 Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix

Kuhn, K, Probstmeier, R, Schachner, M

J Neurochem 1989
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Orthologous Events
SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)
SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)
SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)
SOS binds Grb2 bound to pFAK:NCAM1 (Gallus gallus)
SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2009-02-26)
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