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GUCY1A2 [cytosol]
Stable Identifier
R-HSA-391996
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Guanylate cyclase soluble subunit alpha-2, GCYA2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
NO binds to Guanylate Cyclase (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)
Guanylate cyclase:CO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO:sGC:cinaciguat [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO:sGC:sGC stimulators [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
Cinaciguat binds sGC:NO (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO:sGC:cinaciguat [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO binds to Guanylate Cyclase (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)
Guanylate cyclase:CO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO:sGC:cinaciguat [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO:sGC:sGC stimulators [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
sGC stimulators bind sGC:NO (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
NO:sGC:sGC stimulators [cytosol] (Homo sapiens)
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Guanylate cyclase, soluble [cytosol] (Homo sapiens)
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
GUCY1A2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33402 GUCY1A2
Gene Names
GUCY1A2, GUC1A2, GUCSA2
Chain
chain:1-732
Reference Genes
BioGPS Gene:2977 GUCY1A2
COSMIC (genes):GUCY1A2 GUCY1A2
CTD Gene:2977 GUCY1A2
dbSNP Gene:2977 GUCY1A2
ENSEMBL:ENSG00000152402 GUCY1A2
HGNC:4684 GUCY1A2
Monarch:2977 GUCY1A2
NCBI Gene:2977 GUCY1A2
OMIM:601244 GUCY1A2
UCSC:P33402 GUCY1A2
Reference Transcript
RefSeq:NM_001256424.1 GUCY1A2
RefSeq:NM_000855.2 GUCY1A2
Other Identifiers
11755427_a_at
16743978
206927_PM_s_at
206927_s_at
228731_PM_at
228731_at
228732_PM_at
228732_at
230665_PM_at
230665_at
236335_PM_at
236335_at
242342_PM_at
242342_at
2977
32301_at
32302_g_at
3389666
3389667
3389668
3389669
3389670
3389671
3389672
3389673
3389674
3389675
3389681
3389689
3389690
3389695
3389702
3389722
3389728
3389730
3389734
3389735
3389736
3389737
3389738
3389740
45416_at
47872_at
51717_at
56663_at
60663_at
7951437
A_23_P350001
A_32_P44099
GE55944
GE60421
GE636649
GO:0003824
GO:0004383
GO:0005515
GO:0005525
GO:0005737
GO:0005829
GO:0006182
GO:0007165
GO:0007263
GO:0008074
GO:0009190
GO:0009975
GO:0010750
GO:0016829
GO:0016849
GO:0019934
GO:0020037
GO:0035556
GO:0055086
GO:0070482
GO:1901135
HMNXSV003055619
Hs.134863.0.A1_3p_at
Hs.24321.0.S1_3p_at
Hs.24477.0.A1_3p_at
Hs.74052.0.A1_3p_at
ILMN_1720496
ILMN_1834126
PH_hs_0002141
PH_hs_0004235
PH_hs_0010596
TC11002258.hg
TC11003325.hg
Z50053_at
g4504210_3p_a_at
Participates
as a member of
Guanylate cyclase soluble subunit alpha [cytosol] (Homo sapiens)
Inferred To
Gycalpha99B [cytosol]
(Drosophila melanogaster)
Gucy1a2 [cytosol]
(Mus musculus)
Gucy1a2 [cytosol]
(Rattus norvegicus)
GUCY1A2 [cytosol]
(Bos taurus)
GUCY1A2 [cytosol]
(Canis familiaris)
GUCY1A2 [cytosol]
(Gallus gallus)
GUCY1A2 [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1289
ENSEMBL
ENSP00000282249
,
ENSP00000431245
,
ENST00000347596
,
ENST00000282249
,
ENSP00000344874
,
ENST00000526355
OpenTargets
ENSG00000152402
IntEnz
4.6.1.2
HPA
ENSG00000152402-GUCY1A2
PRO
P33402
Pharos - Targets
P33402
GlyGen
P33402
HMDB Protein
HMDBP01072
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.684
6
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