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ABCC4 [platelet dense granule membrane]
Stable Identifier
R-HSA-391972
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet dense granule membrane
Synonyms
MOAT-B, Multidrug resistance-associated protein 4, MRP4_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
ABCC4 accumulation of dense granule contents (Homo sapiens)
ABCC4 [platelet dense granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15439 ABCC4
Gene Names
ABCC4, MOATB, MRP4
Chain
chain:1-1325
Reference Genes
BioGPS Gene:10257 ABCC4
COSMIC (genes):ABCC4 ABCC4
CTD Gene:10257 ABCC4
dbSNP Gene:10257 ABCC4
ENSEMBL:ENSG00000125257 ABCC4
ENSEMBL_homo_sapiens_GENE:ENSG00000125257.16 ABCC4
HGNC:55 ABCC4
KEGG Gene (Homo sapiens):10257 ABCC4
Monarch:10257 ABCC4
NCBI Gene:10257 ABCC4
OMIM:605250 ABCC4
UCSC:O15439 ABCC4
Reference Transcript
RefSeq:NM_001105515.2 ABCC4
RefSeq:NM_005845.4 ABCC4
RefSeq:NM_001301829.1 ABCC4
RefSeq:NM_001301830.1 ABCC4
Other Identifiers
10257
11719632_a_at
11750651_a_at
11752356_a_at
11758238_s_at
1554918_3p_a_at
1554918_PM_a_at
1554918_a_at
1555039_PM_a_at
1555039_a_at
16780271
1931_at
203196_PM_at
203196_at
34955_at
3521178
3521179
3521183
3521184
3521187
3521189
3521193
3521199
3521203
3521204
3521205
3521207
3521212
3521213
3521219
3521224
3521225
3521233
3521248
3521249
3521250
3521251
3521252
3521253
3521255
3521256
3521264
3521265
3521266
3521271
3521272
3521274
3521276
3521289
3521290
3521291
3521296
3521297
3521311
3521312
72602_at
7972297
91447_at
A_23_P25559
A_24_P16913
A_24_P222291
GE80126
GO:0000166
GO:0001409
GO:0002576
GO:0003013
GO:0003824
GO:0005215
GO:0005515
GO:0005524
GO:0005634
GO:0005730
GO:0005794
GO:0005886
GO:0006805
GO:0006855
GO:0006869
GO:0008559
GO:0015132
GO:0015143
GO:0015216
GO:0015431
GO:0015432
GO:0015562
GO:0015721
GO:0015732
GO:0015747
GO:0016020
GO:0016192
GO:0016323
GO:0016324
GO:0016404
GO:0016491
GO:0016787
GO:0016887
GO:0023052
GO:0031088
GO:0031410
GO:0032310
GO:0034634
GO:0034775
GO:0042626
GO:0042910
GO:0043225
GO:0043226
GO:0044782
GO:0055085
GO:0060271
GO:0070730
GO:0071716
GO:0098591
GO:0098656
GO:0140115
GO:0140359
GO:0140657
GO:0150104
GO:1903790
HMNXSV003018571
HMNXSV003037263
Hs.139336.0.S2_3p_at
Hs2.139336.2.S1_3p_at
Hs2.139336.2.S1_3p_s_at
Hs2.139336.3.S1_3p_s_at
ILMN_1788457
ILMN_2194009
PH_hs_0023674
TC13000799.hg
TC13001638.hg
Other forms of this molecule
ABCC4 [plasma membrane]
Inferred To
abcc4 [platelet dense granule membrane]
(Danio rerio)
LOC515333 [platelet dense granule membrane]
(Bos taurus)
Abcc4 [platelet dense granule membrane]
(Canis familiaris)
Homologues of ABCC4 [platelet dense granule membrane]
(Dictyostelium discoideum)
Homologues of ABCC4 [platelet dense granule membrane]
(Plasmodium falciparum)
mrp-6 [platelet dense granule membrane]
(Caenorhabditis elegans)
ABCC4 [platelet dense granule membrane]
(Dictyostelium discoideum)
ABCC4 [platelet dense granule membrane]
(Gallus gallus)
ABCC4 [platelet dense granule membrane]
(Mus musculus)
ABCC4 [platelet dense granule membrane]
(Plasmodium falciparum)
ABCC4 [platelet dense granule membrane]
(Rattus norvegicus)
ABCC4 [platelet dense granule membrane]
(Sus scrofa)
Dme_CG7627 [platelet dense granule membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001288758.1
,
NP_001288759.1
,
NP_001098985.1
,
NP_005836.2
ZINC - World Drugs
MRP4_HUMAN
Guide to Pharmacology - Targets
782
OpenTargets
ENSG00000125257
ZINC - FDA approved
MRP4_HUMAN
ZINC - Substances
MRP4_HUMAN
ZINC - Biogenic
MRP4_HUMAN
ZINC target
O15439
PRO
O15439
PDB
8BWP
,
8IZ9
,
8J3Z
,
8J3W
,
8IZ7
,
8I4B
,
8IZ8
,
8BJF
,
8IZA
,
8I4C
,
8BWQ
,
8I4A
,
8BWO
,
8BWR
ZINC - Metabolites
MRP4_HUMAN
HPA
ENSG00000125257-ABCC4
GeneCards
O15439
Ensembl
ENSG00000125257
,
ENSP00000442024
,
ENSP00000487081
,
ENST00000629385
,
ENST00000646439
,
ENST00000536256
,
ENSP00000494751
,
ENSP00000494609
,
ENST00000645237
Pharos - Targets
O15439
ZINC - Predictions - Purchasable
MRP4_HUMAN
HMDB Protein
HMDBP03952
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00013 MPP1
1
MPP1 [plasma membrane]
(R-HSA-420423)
0.707
10
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