Reactome | DP1 receptor can bind PGD2

DP1 receptor can bind PGD2

Stable Identifier

R-HSA-391935

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        DP1 receptor can bind PGD2 (Homo sapiens)

General

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DP1 is a G-protein-coupled receptor encoded by the PTGDR gene (Boie Y et al, 1995). Its activity is mainly mediated by the G protein alpha s subunit that stimulates adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+ (Seiler S et al, 1990).

Literature References

PubMed ID	Title	Journal	Year
2171039	SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors Seiler, S, Brassard, CL, Federici, ME	Prostaglandins	1990
7642548	Molecular cloning and characterization of the human prostanoid DP receptor Boie, Y, Sawyer, N, Slipetz, DM, Metters, KM, Abramovitz, M	J Biol Chem	1995