DP1 receptor can bind PGD2

Stable Identifier
R-HSA-391935
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DP1 is a G-protein-coupled receptor encoded by the PTGDR gene (Boie Y et al, 1995). Its activity is mainly mediated by the G protein alpha s subunit that stimulates adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+ (Seiler S et al, 1990).

Literature References
PubMed ID Title Journal Year
2171039 SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors

Seiler, S, Brassard, CL, Federici, ME

Prostaglandins 1990
7642548 Molecular cloning and characterization of the human prostanoid DP receptor

Boie, Y, Sawyer, N, Slipetz, DM, Metters, KM, Abramovitz, M

J Biol Chem 1995
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created