DP1 is a G-protein-coupled receptor encoded by the PTGDR gene (Boie Y et al, 1995). Its activity is mainly mediated by the G protein alpha s subunit that stimulates adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+ (Seiler S et al, 1990).
Slipetz, DM, Sawyer, N, Boie, Y, Abramovitz, M, Metters, KM
Federici, ME, Seiler, S, Brassard, CL
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