Reactome | DP1 receptor can bind PGD2

DP1 receptor can bind PGD2

Stable Identifier

R-HSA-391935

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        DP1 receptor can bind PGD2 (Homo sapiens)

General

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DP1 is a G-protein-coupled receptor encoded by the PTGDR gene (Boie Y et al, 1995). Its activity is mainly mediated by the G protein alpha s subunit that stimulates adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+ (Seiler S et al, 1990).

Literature References

PubMed ID	Title	Journal	Year
7642548	Molecular cloning and characterization of the human prostanoid DP receptor Boie, Y, Sawyer, N, Slipetz, DM, Metters, KM, Abramovitz, M	J Biol Chem	1995
2171039	SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors Seiler, S, Brassard, CL, Federici, ME	Prostaglandins	1990