DP2 receptor can bind PGD2

Stable Identifier
R-HSA-391934
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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G protein-coupled receptor 44 (GPR44) is a GPCR that has recently been found to belong to the prostanoid receptor family and named DP2 (CRTH2) (Marchese A et al, 1999). The effects of PGD2 bound to the receptor are mediated by coupling with the G protein alpha i/o subunit which inhibits cAMP production (Sawyer N et al, 2002).
Literature References
PubMed ID Title Journal Year
10036181 Discovery of three novel orphan G-protein-coupled receptors

Nguyen, T, George, SR, O'Dowd, BF, Nowak, T, Marchese, A, Heng, HH, Lynch, KR, Im, DS, Cheng, R, Sawzdargo, M

Genomics 1999
12466225 Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2

Chateauneuf, A, Sawyer, N, Cauchon, E, Nicholson, DW, Cruz, RP, Gervais, FG, O'Neill, GP, Metters, KM

Br J Pharmacol 2002
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