DP2 receptor can bind PGD2

Stable Identifier
R-HSA-391934
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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G protein-coupled receptor 44 (GPR44) is a GPCR that has recently been found to belong to the prostanoid receptor family and named DP2 (CRTH2) (Marchese A et al, 1999). The effects of PGD2 bound to the receptor are mediated by coupling with the G protein alpha i/o subunit which inhibits cAMP production (Sawyer N et al, 2002).

Literature References
PubMed ID Title Journal Year
12466225 Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2

Sawyer, N, Cauchon, E, Chateauneuf, A, Cruz, RP, Nicholson, DW, Metters, KM, O'Neill, GP, Gervais, FG

Br J Pharmacol 2002
10036181 Discovery of three novel orphan G-protein-coupled receptors

Marchese, A, Sawzdargo, M, Nguyen, T, Cheng, R, Heng, HH, Nowak, T, Im, DS, Lynch, KR, George, SR, O'Dowd, BF

Genomics 1999
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