Reactome | DP2 receptor can bind PGD2

DP2 receptor can bind PGD2

Stable Identifier

R-HSA-391934

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        DP2 receptor can bind PGD2 (Homo sapiens)

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G protein-coupled receptor 44 (GPR44) is a GPCR that has recently been found to belong to the prostanoid receptor family and named DP2 (CRTH2) (Marchese A et al, 1999). The effects of PGD2 bound to the receptor are mediated by coupling with the G protein alpha i/o subunit which inhibits cAMP production (Sawyer N et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
10036181	Discovery of three novel orphan G-protein-coupled receptors Nguyen, T, George, SR, O'Dowd, BF, Nowak, T, Marchese, A, Heng, HH, Lynch, KR, Im, DS, Cheng, R, Sawzdargo, M	Genomics	1999
12466225	Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2 Chateauneuf, A, Sawyer, N, Cauchon, E, Nicholson, DW, Cruz, RP, Gervais, FG, O'Neill, GP, Metters, KM	Br J Pharmacol	2002