FPR2 binds FPR2 ligands

Stable Identifier
R-HSA-391913
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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FPR2 binds FPR2 ligands
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The N-formyl peptide receptor 2 (FPR2, LXA4 receptor, FPRL1) (Ye et al. 1992, Fiore et al. 1994) has been reported to respond to numerous ligand with a broad range of structural diversity (Migeotte et al. 2006). It was originally identified as a low-affinity receptor for N-formyl-methionyl peptides but has greater affinity for many ligands including lipoxin A4 (Fiore et al. 1994, Migeotte et al. 2006), annexin-1 (Perretti et al. 2002), the truncated chemokine sCKbeta8-1 (Elagoz et al. 2004) and humanin (Ying et al. 2004).
Literature References
PubMed ID Title Journal Year
1374236 Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor

Cochrane, CG, Ye, RD, Quehenberger, O, Prossnitz, ER, Cavanagh, SL

Biochem Biophys Res Commun 1992
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Orthologous Events
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Authored
Jassal, B  (2009-03-26)
Reviewed
D'Eustachio, P  (2009-05-29)
Created
Jassal, B  (2009-02-25)
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