Autophosphorylation of NCAM1 bound Fyn

Stable Identifier
R-HSA-391871
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Autophosphorylation of NCAM1 bound Fyn
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The Tyr420 residue located in the activation loop of Fyn is responsible for its enzymatic activity. Once the Tyr531 in its negative regulatory site is dephosphorylated by RPTPalpha, Fyn undergoes autophosphorylation on Tyr420 for its maximum activity.
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Output
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Catalyst Activity

protein tyrosine kinase activity of Fyn:NCAM1:RPTP-alpha [plasma membrane]

Physical Entity
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Autophosphorylation of NCAM1 bound Fyn (Mus musculus)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2009-02-24)
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