Fyn constitutively associates with the 140 kD isoform of NCAM1 in the plasma membrane, probably indirectly. Fyn is attached to the lipid raft membrane compartment via palmitoylation and is inactivated by tyrosine phosphorylation (Y531) within its C-terminal regulatory region. Fyn kinase has two well-known phosphorylation sites which affect its activity in opposite ways. The phosphorylation of Tyr531 located in the C-terminus of the protein inhibits the Fyn kinase activity, due to the binding of this tyrosine residue to the SH2 domain of the protein, which stabilizes its catalytically inactive conformation.
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