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PTGER4 [plasma membrane]
Stable Identifier
R-HSA-391832
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EP4 receptor, RecName: Full=Prostaglandin E2 receptor EP4 subtype; Short=PGE receptor, EP4 subtype; AltName: Full=Prostanoid EP4 receptor;
GN Name=PTGER4; Synonyms=PTGER2;
OS Homo sapiens, PE2R4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGER2,PTGER4:PGE2 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGER2,PTGER4:PGE2 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGER2,PTGER4:PGE2 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGER2,PTGER4:PGE2 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGER2,PTGER4:PGE2 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
EP2 and EP4 receptors can bind PGE2 (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4:PGE2 [plasma membrane] (Homo sapiens)
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
PTGER4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35408 PTGER4
Gene Names
PTGER4, PTGER2
Chain
chain:1-488
Reference Genes
BioGPS Gene:5734 PTGER4
COSMIC (genes):PTGER2 PTGER4
COSMIC (genes):PTGER4 PTGER4
CTD Gene:5734 PTGER4
dbSNP Gene:5734 PTGER4
ENSEMBL:ENSG00000171522 PTGER4
HGNC:9596 PTGER4
KEGG:hsa:5734 PTGER4
Monarch:5734 PTGER4
NCBI Gene:5734 PTGER4
OMIM:601586 PTGER4
UCSC:P35408 PTGER4
Reference Transcript
RefSeq:NM_000958.2 PTGER4
Other Identifiers
1118_at
11725793_s_at
11725794_at
16984287
204896_PM_s_at
204896_s_at
204897_PM_at
204897_at
2807631
2807632
2807633
2807634
2807638
2807639
2807644
33772_at
50746_at
5734
8105067
A_14_P108959
A_23_P148047
A_23_P435394
GE57688
GO:0001818
GO:0001819
GO:0002376
GO:0004930
GO:0004955
GO:0004957
GO:0005515
GO:0005886
GO:0006954
GO:0006955
GO:0007186
GO:0007188
GO:0007189
GO:0007193
GO:0007204
GO:0007254
GO:0009612
GO:0009624
GO:0016020
GO:0030154
GO:0030278
GO:0032496
GO:0033624
GO:0034695
GO:0042093
GO:0048856
GO:0050728
GO:0050729
GO:0051492
GO:0060089
GO:0060348
GO:0070371
GO:0071260
GO:0071380
GO:2000420
HMNXSV003032057
HMNXSV003038865
Hs.199248.0.S1_3p_a_at
Hs.199248.0.S3_3p_at
ILMN_1795930
L28175_at
PH_hs_0011702
TC05000184.hg
Participates
as a member of
PTGER2,PTGER4 [plasma membrane] (Homo sapiens)
Inferred To
ptger4 [plasma membrane]
(Xenopus tropicalis)
Ptger4 [plasma membrane]
(Mus musculus)
Ptger4 [plasma membrane]
(Rattus norvegicus)
BcDNA:GH27361 [plasma membrane]
(Drosophila melanogaster)
EP4 [plasma membrane]
(Gallus gallus)
ptger4a [plasma membrane]
(Danio rerio)
PTGER4 [plasma membrane]
(Bos taurus)
PTGER4 [plasma membrane]
(Canis familiaris)
PTGER4 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000949.1
ZINC - World Drugs
PE2R4_HUMAN
Guide to Pharmacology - Targets
343
ENSEMBL
ENST00000302472
,
ENSP00000302846
OpenTargets
ENSG00000171522
ZINC - FDA approved
PE2R4_HUMAN
ZINC - Substances
PE2R4_HUMAN
ZINC - Biogenic
PE2R4_HUMAN
ZINC target
P35408
PRO
P35408
GlyGen
P35408
PDB
8GCP
,
8GDA
,
8GDB
,
7D7M
,
5YHL
,
8GCM
,
8GD9
,
5YWY
ZINC - Investigational
PE2R4_HUMAN
ZINC - Metabolites
PE2R4_HUMAN
HPA
ENSG00000171522-PTGER4
Pharos - Targets
P35408
ZINC - Predictions - Purchasable
PE2R4_HUMAN
HMDB Protein
HMDBP02789
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