Luteininzing hormone (LH, lutropin) is a dimeric glycoprotein synthesized in the anterior pituitary gland. It triggers ovulation in females and stimulates Leydig cell production of testosterone in males. It mediates its action by binding to the LH receptor (Minegishi T et al, 1990, Jia XC et al, 1991), which is found in the ovary, testes and uterus. The activated receptor couples to the G protein alpha-s subunit (Gilchrist RL et al, 1996) which activates adenylate cyclase and increases intracellular cAMP levels.
Gilchrist, RL, Ryu, KS, Ji, I, Ji, TH
Jia, XC, Oikawa, M, Bo, M, Tanaka, T, Ny, T, Boime, I, Hsueh, AJ
Minegishi, T, Nakamura, K, Takakura, Y, Miyamoto, K, Hasegawa, Y, Ibuki, Y, Igarashi, M, Minegish T [corrected to Minegishi, T
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