Luteinizing hormone receptor can bind LH

Stable Identifier
R-HSA-391377
Type
Reaction [binding]
Species
Homo sapiens
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Luteininzing hormone (LH, lutropin) is a dimeric glycoprotein synthesized in the anterior pituitary gland. It triggers ovulation in females and stimulates Leydig cell production of testosterone in males. It mediates its action by binding to the LH receptor (Minegishi T et al, 1990, Jia XC et al, 1991), which is found in the ovary, testes and uterus. The activated receptor couples to the G protein alpha-s subunit (Gilchrist RL et al, 1996) which activates adenylate cyclase and increases intracellular cAMP levels.

Literature References
PubMed ID Title Journal Year
8702611 The luteinizing hormone/chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals

Gilchrist, RL, Ryu, KS, Ji, I, Ji, TH

J Biol Chem 1996
1922095 Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species

Jia, XC, Oikawa, M, Bo, M, Tanaka, T, Ny, T, Boime, I, Hsueh, AJ

Mol Endocrinol 1991
2244890 Cloning and sequencing of human LH/hCG receptor cDNA

Minegishi, T, Nakamura, K, Takakura, Y, Miyamoto, K, Hasegawa, Y, Ibuki, Y, Igarashi, M, Minegish T [corrected to Minegishi, T

Biochem Biophys Res Commun 1990
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