Reactome | Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin

Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin

Stable Identifier

R-HSA-391375

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Thyroid-stimulating hormone (TSH, thyrotropin) is a dimeric glycoprotein synthesized and secreted by thyrotrope cells in the anterior pituitary gland. TSH regulates the endocrine function of the thyroid gland, mediating the release of the hormones thyroxine (T4) and triiodothyronine (T3). Thyrostimulin is a dimer of Glycoprotein hormone alpha-2 (GPHA2) and Glycoprotein hormone beta-5(GPHB5), comprising the a fifth glycoprotein hormone (Nakabayashi et al. 2002), a more potent ligand for the TSH receptor than TSH which has a wider tissue distribution (Huang et al. 2016). These effects are mediated by the TSH receptor (Nagayama Y et al, 1989), found primarily on thyroid follicular cells. The activated receptor couples with the G protein alpha-s subunit (Allgeier A et al 1994) which activates adeylate cyclase and increases intracellular cAMP levels.

Literature References

PubMed ID	Title	Journal	Year
12045258	Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor Nakabayashi, K, Hsueh, AJ, Mosselman, S, Bae, J, Matsumi, H, Hsu, SY, Bhalla, A	J. Clin. Invest.	2002
8188646	The human thyrotropin receptor activates G-proteins Gs and Gq/11 Schultz, G, Dumont, JE, Offermanns, S, Spicher, K, Allgeier, A, Van Sande, J	J Biol Chem	1994
2558651	Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor Nagayama, Y, Seto, P, Rapoport, B, Kaufman, KD	Biochem Biophys Res Commun	1989