Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin

Stable Identifier
R-HSA-391375
Type
Reaction [binding]
Species
Homo sapiens
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Thyroid-stimulating hormone (TSH, thyrotropin) is a dimeric glycoprotein synthesized and secreted by thyrotrope cells in the anterior pituitary gland. TSH regulates the endocrine function of the thyroid gland, mediating the release of the hormones thyroxine (T4) and triiodothyronine (T3). Thyrostimulin is a dimer of Glycoprotein hormone alpha-2 (GPHA2) and Glycoprotein hormone beta-5(GPHB5), comprising the a fifth glycoprotein hormone (Nakabayashi et al. 2002), a more potent ligand for the TSH receptor than TSH which has a wider tissue distribution (Huang et al. 2016). These effects are mediated by the TSH receptor (Nagayama Y et al, 1989), found primarily on thyroid follicular cells. The activated receptor couples with the G protein alpha-s subunit (Allgeier A et al 1994) which activates adeylate cyclase and increases intracellular cAMP levels.

Literature References
PubMed ID Title Journal Year
8188646 The human thyrotropin receptor activates G-proteins Gs and Gq/11

Allgeier, A, Offermanns, S, Van Sande, J, Spicher, K, Schultz, G, Dumont, JE

J Biol Chem 1994
12045258 Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

Nakabayashi, K, Matsumi, H, Bhalla, A, Bae, J, Mosselman, S, Hsu, SY, Hsueh, AJ

J. Clin. Invest. 2002
2558651 Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor

Nagayama, Y, Kaufman, KD, Seto, P, Rapoport, B

Biochem Biophys Res Commun 1989
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