unfolded CCT/TRiC substrate candidates [cytosol]

Stable Identifier
Set [CandidateSet]
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
21098288 Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl

Lu, J, Chiang, J, Iyer, RR, Thompson, E, Kaneski, CR, Xu, DS, Yang, C, Chen, M, Hodes, RJ, Lonser, RR, Brady, RO, Zhuang, Z

Proc. Natl. Acad. Sci. U.S.A. 2010
25467444 Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

Freund, A, Zhong, FL, Venteicher, AS, Meng, Z, Veenstra, TD, Frydman, J, Artandi, SE

Cell 2014
24756126 Modulation of STAT3 folding and function by TRiC/CCT chaperonin

Kasembeli, M, Lau, WC, Roh, SH, Eckols, TK, Frydman, J, Chiu, W, Tweardy, DJ

PLoS Biol. 2014
23747015 Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity

Trinidad, AG, Muller, PA, Cuellar, J, Klejnot, M, Nobis, M, Valpuesta, JM, Vousden, KH

Mol. Cell 2013
9819444 Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT

Won, KA, Schumacher, RJ, Farr, GW, Horwich, AL, Reed, SI

Mol. Cell. Biol. 1998
25342745 The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation

Miyata, Y, Shibata, T, Aoshima, M, Tsubata, T, Nishida, E

J. Biol. Chem. 2014
21995946 Chaperonin TRiC assists the refolding of sperm-specific glyceraldehyde-3-phosphate dehydrogenase

Naletova, IN, Popova, KM, Eldarov, MA, Kuravsky, ML, Schmalhausen, EV, Sevostyanova, IA, Muronetz, VI

Arch. Biochem. Biophys. 2011
12502735 Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex

Guenther, MG, Yu, J, Kao, GD, Yen, TJ, Lazar, MA

Genes Dev. 2002
19011634 Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

Yam, AY, Xia, Y, Lin, HT, Burlingame, A, Gerstein, M, Frydman, J

Nat Struct Mol Biol 2008
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