Reactome | TAAR3 [plasma membrane]

TAAR3 [plasma membrane]

Stable Identifier

R-HSA-391204

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Putative trace amine-associated receptor 3; AltName: Full=G-protein coupled receptor 57; GN Name=TAAR3; Synonyms=GPR57; OS Homo sapiens, TAAR3_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Trace amine-associated receptors can bind trace amines (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P1P4 TAAR3

Gene Names

TAAR3, GPR57, TAAR3P

Chain

chain:1-343

Reference Genes

HGNC:4513 TAAR3

UCSC:Q9P1P4 TAAR3

Participates

as a candidate of

Trace amine-associated receptor [plasma membrane] (Homo sapiens)

Inferred To

taar12e [plasma membrane] (Danio rerio)

taar15 [plasma membrane] (Danio rerio)

Homologues of TAAR3 [plasma membrane] (Danio rerio)

TAAR3 [plasma membrane] (Bos taurus)

Taar3 [plasma membrane] (Mus musculus)

Taar3 [plasma membrane] (Rattus norvegicus)

npr-42 [plasma membrane] (Caenorhabditis elegans)

taar14f [plasma membrane] (Danio rerio)

taar12b [plasma membrane] (Danio rerio)

taar12f [plasma membrane] (Danio rerio)

taar14e [plasma membrane] (Danio rerio)

taar12g [plasma membrane] (Danio rerio)

Cross References

Guide to Pharmacology - Targets

168

OpenTargets

ENSG00000179073

GeneCards

TAAR3P

PRO

Q9P1P4

Pharos - Targets

Q9P1P4

GlyGen

Q9P1P4