SIRP gamma binds CD47

Stable Identifier
R-HSA-391168
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SIRP gamma (SIRPG) is expressed by T cells and has been shown to engage with CD47, albeit with lower affinity than SIRP alpha. The engagement of SIRPG on the surface of T cells increased cell-cell adhesion.

Literature References
PubMed ID Title Journal Year
15383453 Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation

Piccio, L, Vermi, W, Boles, KS, Fuchs, A, Strader, CA, Facchetti, F, Cella, M, Colonna, M

Blood 2005
15294972 Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family

Brooke, G, Holbrook, JD, Brown, MH, Barclay, AN

J Immunol 2004
10572074 Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47

Seiffert, M, Cant, C, Chen, Z, Rappold, I, Brugger, W, Kanz, L, Brown, EJ, Ullrich, A, Buhring, HJ

Blood 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
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