SIRP gamma binds CD47

Stable Identifier
Reaction [binding]
Homo sapiens
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SIRP gamma (SIRPG) is expressed by T cells and has been shown to engage with CD47, albeit with lower affinity than SIRP alpha. The engagement of SIRPG on the surface of T cells increased cell-cell adhesion.

Literature References
PubMed ID Title Journal Year
15294972 Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family

Brooke, G, Barclay, AN, Brown, MH, Holbrook, JD

J Immunol 2004
15383453 Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation

Strader, CA, Facchetti, F, Boles, KS, Piccio, L, Colonna, M, Cella, M, Vermi, W, Fuchs, A

Blood 2005
10572074 Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47

Chen, Z, Cant, C, Brown, EJ, Brugger, W, Buhring, HJ, Kanz, L, Ullrich, A, Rappold, I, Seiffert, M

Blood 1999
Orthologous Events
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