Reactome | SIRP gamma binds CD47

SIRP gamma binds CD47

Stable Identifier

R-HSA-391168

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SIRP gamma (SIRPG) is expressed by T cells and has been shown to engage with CD47, albeit with lower affinity than SIRP alpha. The engagement of SIRPG on the surface of T cells increased cell-cell adhesion.

Literature References

PubMed ID	Title	Journal	Year
15294972	Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family Brooke, G, Holbrook, JD, Brown, MH, Barclay, AN	J Immunol	2004
15383453	Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation Piccio, L, Vermi, W, Boles, KS, Fuchs, A, Strader, CA, Facchetti, F, Cella, M, Colonna, M	Blood	2005
10572074	Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47 Seiffert, M, Cant, C, Chen, Z, Rappold, I, Brugger, W, Kanz, L, Brown, EJ, Ullrich, A, Buhring, HJ	Blood	1999