Reactome | SIRP alpha binds CD47

SIRP alpha binds CD47

Stable Identifier

R-HSA-391158

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CD47 is an extracellular ligand for SIRP alpha. SIRP alpha directly binds to the loops of the Ig variable like domain of CD47 in an end-to-end fashion. The SIRP alpha/CD47 interaction is unusual in that it can lead to bidirectional signaling through SIRP alpha and CD47. The major function of this interaction is prevention of phagocytosis of RBC and platelets by macrophages.

Literature References

PubMed ID	Title	Journal	Year
18657508	Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47 Harlos, K, Barclay, AN, Graham, SC, Stuart, DI, Turner, J, Hatherley, D	Mol Cell	2008
17070842	Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47 Zhou, Y, Tong, Q, Liu, Y, Chen, Y-T, Buhring, HJ, Zen, K, Ha, B, Lee, HW, Yang, Y, Chen, CX, Yang, JJ	J Mol Biol	2007
19628875	Structure of signal-regulatory protein alpha: a link to antigen receptor evolution Harlos, K, Barclay, AN, Graham, SC, Stuart, DI, Hatherley, D	J Biol Chem	2009
17369261	The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors Harlos, K, Dunlop, DC, Barclay, AN, Stuart, DI, Hatherley, D	J Biol Chem	2007
10572074	Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47 Chen, Z, Cant, C, Brown, EJ, Brugger, W, Buhring, HJ, Kanz, L, Ullrich, A, Rappold, I, Seiffert, M	Blood	1999