SIRPA binds SFTPA oligomer, SFTPD oligomer

Stable Identifier
R-HSA-391155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Pulmonary surfactant-associated proteins A1, A2 and D (SFTPA1, SFTPA2 and SFTPD) are soluble multivalent ligands shown to bind SIRP alpha (SIRPA) on resident alveolar cells and macrophages via their lectin domain (globular head). SFTPA and SFTPD bind to the same region of SIRPA as CD47, blocking subsequent binding of CD47.

Literature References
PubMed ID Title Journal Year
16213021 Surfactant proteins SP-A and SP-D: structure, function and receptors

Kishore, U, Greenhough, TJ, Waters, P, Shrive, AK, Ghai, R, Kamran, MF, Bernal, AL, Reid, KB, Madan, T, Chakraborty, T

Mol Immunol 2006
14531999 By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation

Gardai, SJ, Xiao, YQ, Dickinson, M, Nick, JA, Voelker, DR, Greene, KE, Henson, PM

Cell 2003
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Orthologous Events
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