Pulmonary surfactant-associated proteins A1, A2 and D (SFTPA1, SFTPA2 and SFTPD) are soluble multivalent ligands shown to bind SIRP alpha (SIRPA) on resident alveolar cells and macrophages via their lectin domain (globular head). SFTPA and SFTPD bind to the same region of SIRPA as CD47, blocking subsequent binding of CD47.
Xiao, YQ, Gardai, SJ, Voelker, DR, Dickinson, M, Henson, PM, Nick, JA, Greene, KE
Kishore, U, Madan, T, Shrive, AK, Greenhough, TJ, Waters, P, Chakraborty, T, Reid, KB, Bernal, AL, Ghai, R, Kamran, MF
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