Reactome | SIRPA binds SFTPA oligomer, SFTPD oligomer

SIRPA binds SFTPA oligomer, SFTPD oligomer

Stable Identifier

R-HSA-391155

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SIRPA binds SFTPA oligomer, SFTPD oligomer

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pulmonary surfactant-associated proteins A1, A2 and D (SFTPA1, SFTPA2 and SFTPD) are soluble multivalent ligands shown to bind SIRP alpha (SIRPA) on resident alveolar cells and macrophages via their lectin domain (globular head). SFTPA and SFTPD bind to the same region of SIRPA as CD47, blocking subsequent binding of CD47.

Literature References

PubMed ID	Title	Journal	Year
14531999	By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation Xiao, YQ, Gardai, SJ, Voelker, DR, Dickinson, M, Henson, PM, Nick, JA, Greene, KE	Cell	2003
16213021	Surfactant proteins SP-A and SP-D: structure, function and receptors Kishore, U, Madan, T, Shrive, AK, Greenhough, TJ, Waters, P, Chakraborty, T, Reid, KB, Bernal, AL, Ghai, R, Kamran, MF	Mol Immunol	2006