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HTR4 [plasma membrane]
Stable Identifier
R-HSA-391008
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
5-HT4 receptor, RecName: Full=5-hydroxytryptamine receptor 4; Short=5-HT-4; Short=5-HT4; AltName: Full=Serotonin receptor 4;
GN Name=HTR4;
OS Homo sapiens, 5HT4R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13639 HTR4
Gene Names
HTR4
Chain
chain:1-388
Reference Genes
BioGPS Gene:3360 HTR4
COSMIC (genes):HTR4 HTR4
CTD Gene:3360 HTR4
dbSNP Gene:3360 HTR4
ENSEMBL:ENSG00000164270 HTR4
HGNC:5299 HTR4
KEGG:hsa:3360 HTR4
Monarch:3360 HTR4
NCBI Gene:3360 HTR4
OMIM:602164 HTR4
UCSC:Q13639 HTR4
Reference Transcript
RefSeq:NM_001040173.2 HTR4
RefSeq:NM_000870.6 HTR4
RefSeq:NM_199453.3 HTR4
RefSeq:NM_001286410.1 HTR4
RefSeq:NM_001040172.2 HTR4
RefSeq:NM_001040169.2 HTR4
Other Identifiers
11735356_a_at
11742130_a_at
17001374
207577_PM_at
207577_at
207578_PM_s_at
207578_s_at
216939_PM_s_at
216939_s_at
2880553
2880554
2880558
2880564
2880565
2880566
2880567
2880568
2880569
2880572
2880577
2880578
2880579
2880581
2880586
2880587
2880598
2880599
2880600
2880601
2880602
2880603
2880605
2880606
2880607
2880609
2880611
2880615
2880616
3360
34466_at
34467_g_at
34468_at
8114977
A_23_P133637
A_24_P234768
A_24_P316335
GE563797
GO:0004930
GO:0004993
GO:0005515
GO:0005737
GO:0005768
GO:0005886
GO:0007186
GO:0007187
GO:0007188
GO:0007189
GO:0007192
GO:0007268
GO:0016020
GO:0022600
GO:0023052
GO:0030277
GO:0030425
GO:0030594
GO:0031410
GO:0032098
GO:0043226
GO:0045202
GO:0060089
GO:0070254
GO:0098664
GO:0098794
GO:0098978
GO:0099589
GO:0120056
GO:0150052
HMNXSV003044670
HMNXSV003052077
Hs.113262.0.S2_3p_at
Hs.113262.1.S1_3p_a_at
ILMN_1676350
ILMN_1786080
ILMN_1808258
ILMN_2410905
PH_hs_0006236
g11321562_3p_a_at
Participates
as a member of
HTR4,6,7 [plasma membrane] (Homo sapiens)
Inferred To
Dop1R1 [plasma membrane]
(Drosophila melanogaster)
dop-1 [plasma membrane]
(Caenorhabditis elegans)
HTR4 [plasma membrane]
(Bos taurus)
HTR4 [plasma membrane]
(Canis familiaris)
HTR4 [plasma membrane]
(Gallus gallus)
HTR4 [plasma membrane]
(Mus musculus)
HTR4 [plasma membrane]
(Rattus norvegicus)
HTR4 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001273339.1
,
NP_001035262.2
,
NP_000861.1
,
NP_001035263.1
,
NP_001035259.1
,
NP_955525.1
Guide to Pharmacology - Targets
9
OpenTargets
ENSG00000164270
ENSEMBL
ENST00000360693
,
ENST00000517929
,
ENSP00000367120
,
ENST00000521530
,
ENSP00000353915
,
ENSP00000427913
,
ENST00000522588
,
ENST00000520514
,
ENST00000521735
,
ENSP00000428320
,
ENST00000377888
,
ENSG00000164270
,
ENSP00000430874
,
ENSP00000435904
,
ENSP00000430979
ZINC - Substances
5HT4R_HUMAN
ZINC - Biogenic
5HT4R_HUMAN
ZINC target
Q13639
PRO
Q13639
GlyGen
Q13639
PDB
7XT9
,
7XT8
,
5EM9
,
7XTA
ZINC - Investigational
5HT4R_HUMAN
ZINC - Metabolites
5HT4R_HUMAN
HPA
ENSG00000164270-HTR4
GeneCards
HTR4
Pharos - Targets
Q13639
ZINC - Predictions - Purchasable
5HT4R_HUMAN
HMDB Protein
HMDBP02219
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.581
5
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