Reactome | HTR5A [plasma membrane]

HTR5A [plasma membrane]

Stable Identifier

R-HSA-391007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-HT5A receptor, RecName: Full=5-hydroxytryptamine receptor 5A; Short=5-HT-5A; Short=5-HT-5; AltName: Full=Serotonin receptor 5A;
GN Name=HTR5A;
OS Homo sapiens, 5HT5A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        HTR1 and 5A receptors can bind serotonin (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR5A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P47898 HTR5A

Gene Names

HTR5A

Chain

chain:1-357

Reference Genes

BioGPS Gene:3361 HTR5A

COSMIC (genes):HTR5A HTR5A

CTD Gene:3361 HTR5A

dbSNP Gene:3361 HTR5A

ENSEMBL:ENSG00000157219 HTR5A

ENSEMBL:ENSG00000157219.5 HTR5A

HGNC:5300 HTR5A

KEGG Gene (Homo sapiens):3361 HTR5A

Monarch:3361 HTR5A

NCBI Gene:3361 HTR5A

OMIM:601305 HTR5A

UCSC:P47898 HTR5A

Reference Transcript

RefSeq:NM_024012.3 HTR5A

Other Identifiers

11736514_at

11736515_a_at

17053872

221362_PM_at

221362_at

3033128

3033129

3033135

3033136

3033137

3361

8137517

A_23_P304373

A_23_P42565

GE60069

GO:0004930

GO:0004993

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007189

GO:0007198

GO:0007268

GO:0016020

GO:0021766

GO:0023052

GO:0030425

GO:0030594

GO:0032355

GO:0043204

GO:0043226

GO:0048856

GO:0051378

GO:0060089

GO:0098664

GO:0099634

HMNXSV003055205

ILMN_1721147

PH_hs_0022168

TC07001035.hg

g13236496_3p_at

Participates

as a member of

HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)

Inferred To

5-HT1B [plasma membrane] (Drosophila melanogaster)

Htr5a [plasma membrane] (Mus musculus)

Htr5a [plasma membrane] (Rattus norvegicus)

htr5a [plasma membrane] (Danio rerio)

htr5a [plasma membrane] (Xenopus tropicalis)

Homologues of HTR5A [plasma membrane] (Drosophila melanogaster)

5-HT1A [plasma membrane] (Drosophila melanogaster)

ser-4 [plasma membrane] (Caenorhabditis elegans)

HTR5A [plasma membrane] (Bos taurus)

HTR5A [plasma membrane] (Canis familiaris)

HTR5A [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_076917.1

ZINC - World Drugs

5HT5A_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000157219

ZINC - FDA approved

5HT5A_HUMAN

ZINC - Substances

5HT5A_HUMAN

ZINC - Biogenic

5HT5A_HUMAN

ZINC target

P47898

PRO

P47898

PDB

7X5H, 7UM5, 7UM7, 7UM4, 7UM6

ZINC - Investigational

5HT5A_HUMAN

ZINC - Metabolites

5HT5A_HUMAN

GeneCards

P47898

HPA

ENSG00000157219-HTR5A

Ensembl

ENST00000287907, ENSP00000287907, ENSG00000157219

Pharos - Targets

P47898

ZINC - Predictions - Purchasable

5HT5A_HUMAN

HMDB Protein

HMDBP10859