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HTR5A [plasma membrane]
Stable Identifier
R-HSA-391007
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
5-HT5A receptor, RecName: Full=5-hydroxytryptamine receptor 5A; Short=5-HT-5A; Short=5-HT-5; AltName: Full=Serotonin receptor 5A;
GN Name=HTR5A;
OS Homo sapiens, 5HT5A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
HTR1 and 5A receptors can bind serotonin (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR5A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47898 HTR5A
Gene Names
HTR5A
Chain
chain:1-357
Reference Genes
BioGPS Gene:3361 HTR5A
COSMIC (genes):HTR5A HTR5A
CTD Gene:3361 HTR5A
dbSNP Gene:3361 HTR5A
ENSEMBL:ENSG00000157219 HTR5A
HGNC:5300 HTR5A
KEGG:hsa:3361 HTR5A
Monarch:3361 HTR5A
NCBI Gene:3361 HTR5A
OMIM:601305 HTR5A
UCSC:P47898 HTR5A
Reference Transcript
RefSeq:NM_024012.4 HTR5A
Other Identifiers
11736514_at
11736515_a_at
17053872
221362_PM_at
221362_at
3033128
3033129
3033132
3033135
3033136
3033137
3361
8137517
A_23_P304373
A_23_P42565
GE60069
GO:0001586
GO:0004930
GO:0004993
GO:0005886
GO:0007186
GO:0007187
GO:0007189
GO:0007198
GO:0007268
GO:0016020
GO:0021766
GO:0023052
GO:0030425
GO:0030594
GO:0032355
GO:0043204
GO:0048856
GO:0060089
GO:0098664
GO:0099589
GO:0099634
HMNXSV003055205
ILMN_1721147
PH_hs_0022168
TC07001035.hg
g13236496_3p_at
Participates
as a member of
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
Inferred To
5-HT1B [plasma membrane]
(Drosophila melanogaster)
Htr5a [plasma membrane]
(Mus musculus)
Htr5a [plasma membrane]
(Rattus norvegicus)
Homologues of HTR5A [plasma membrane]
(Caenorhabditis elegans)
Homologues of HTR5A [plasma membrane]
(Drosophila melanogaster)
htr5aa [plasma membrane]
(Danio rerio)
5-HT1A [plasma membrane]
(Drosophila melanogaster)
ser-4 [plasma membrane]
(Caenorhabditis elegans)
dop-2 [plasma membrane]
(Caenorhabditis elegans)
HTR5A [plasma membrane]
(Bos taurus)
HTR5A [plasma membrane]
(Canis familiaris)
HTR5A [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_076917.1
ZINC - World Drugs
5HT5A_HUMAN
Guide to Pharmacology - Targets
10
ENSEMBL
ENSP00000287907
,
ENST00000287907
,
ENSG00000157219
OpenTargets
ENSG00000157219
ZINC - FDA approved
5HT5A_HUMAN
ZINC - Substances
5HT5A_HUMAN
ZINC - Biogenic
5HT5A_HUMAN
ZINC target
P47898
PRO
P47898
GlyGen
P47898
PDB
7UM4
,
7UM5
,
7UM7
,
7X5H
,
7UM6
ZINC - Investigational
5HT5A_HUMAN
ZINC - Metabolites
5HT5A_HUMAN
GeneCards
HTR5A
HPA
ENSG00000157219-HTR5A
Pharos - Targets
P47898
ZINC - Predictions - Purchasable
5HT5A_HUMAN
HMDB Protein
HMDBP10859
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