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HTR1F [plasma membrane]
Stable Identifier
R-HSA-390979
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
5-HT1F receptor, RecName: Full=5-hydroxytryptamine receptor 1F; Short=5-HT-1F; AltName: Full=Serotonin receptor 1F;
GN Name=HTR1F; Synonyms=HTR1EL;
OS Homo sapiens, 5HT1F_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
HTR1 and 5A receptors can bind serotonin (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
HTR1F [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30939 HTR1F
Gene Names
HTR1F, HTR1EL
Chain
chain:1-366
Reference Genes
BioGPS Gene:3355 HTR1F
COSMIC (genes):HTR1F HTR1F
CTD Gene:3355 HTR1F
dbSNP Gene:3355 HTR1F
ENSEMBL:ENSG00000179097 HTR1F
ENSEMBL_homo_sapiens_GENE:ENSG00000179097.7 HTR1F
HGNC:5292 HTR1F
KEGG Gene (Homo sapiens):3355 HTR1F
Monarch:3355 HTR1F
NCBI Gene:3355 HTR1F
OMIM:182134 HTR1F
UCSC:P30939 HTR1F
Reference Transcript
RefSeq:NM_001322210.1 HTR1F
RefSeq:NM_000866.4 HTR1F
RefSeq:XM_005264751.3 HTR1F
RefSeq:NM_001322208.1 HTR1F
RefSeq:XM_011533664.2 HTR1F
RefSeq:NM_001322209.1 HTR1F
Other Identifiers
11740561_at
16942919
221458_PM_at
221458_at
2631941
2631942
2631945
2631974
2631975
2631976
2631977
2631978
2631979
3355
8081067
A_14_P123815
A_23_P166674
A_33_P3406836
GE80212
GO:0004930
GO:0004993
GO:0005886
GO:0007165
GO:0007186
GO:0007187
GO:0007193
GO:0007198
GO:0007268
GO:0016020
GO:0023052
GO:0030425
GO:0030594
GO:0045202
GO:0051378
GO:0060089
HMNXSV003039377
HMNXSV003040602
ILMN_1685285
L05597_at
PH_hs_0013159
TC03000463.hg
g10835196_3p_at
Participates
as a member of
HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
Inferred To
HTR1F [plasma membrane]
(Bos taurus)
HTR1F [plasma membrane]
(Canis familiaris)
HTR1F [plasma membrane]
(Gallus gallus)
HTR1F [plasma membrane]
(Mus musculus)
HTR1F [plasma membrane]
(Rattus norvegicus)
HTR1F [plasma membrane]
(Sus scrofa)
octr-1 [plasma membrane]
(Caenorhabditis elegans)
htr1f [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001309137.1
,
XP_011531966.1
,
NP_001309138.1
,
NP_000857.1
,
XP_005264808.1
,
NP_001309139.1
ZINC - World Drugs
5HT1F_HUMAN
Guide to Pharmacology - Targets
5
OpenTargets
ENSG00000179097
ZINC - FDA approved
5HT1F_HUMAN
ZINC - Substances
5HT1F_HUMAN
ZINC target
P30939
ZINC - Biogenic
5HT1F_HUMAN
PRO
P30939
PDB
7EXD
ZINC - Metabolites
5HT1F_HUMAN
GeneCards
P30939
HPA
ENSG00000179097-HTR1F
Ensembl
ENSP00000322924
,
ENSG00000179097
,
ENST00000319595
Pharos - Targets
P30939
ZINC - Predictions - Purchasable
5HT1F_HUMAN
HMDB Protein
HMDBP02464
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