Reactome | HTR1F [plasma membrane]

HTR1F

Stable Identifier

R-HSA-390979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-HT1F receptor, RecName: Full=5-hydroxytryptamine receptor 1F; Short=5-HT-1F; AltName: Full=Serotonin receptor 1F;
GN Name=HTR1F; Synonyms=HTR1EL;
OS Homo sapiens, 5HT1F_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        GPCRs that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        5-HT1 and 5A receptors can bind serotonin (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1A,B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1F [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30939 HTR1F

Gene Names

HTR1F, HTR1EL

Chain

chain:1-366

Reference Genes

BioGPS Gene:3355 HTR1F

COSMIC (genes):HTR1F HTR1F

CTD Gene:3355 HTR1F

dbSNP Gene:3355 HTR1F

ENSEMBL:ENSG00000179097 HTR1F

HGNC:5292 HTR1F

KEGG Gene (Homo sapiens):hsa:3355 HTR1F

Monarch:3355 HTR1F

NCBI Gene:3355 HTR1F

OMIM:182134 HTR1F

UCSC:P30939 HTR1F

Reference Transcript

Other Identifiers

0000580239

11740561_at

16942919

221458_at

2631974

2631975

2631976

2631977

2631978

2631979

3355

5555

8081067

A_14_P123815

A_23_P166674

A_33_P3406836

AAA36605

AAA36646

AAH69125

AAM21128

AC119733

AF498981

BC069125

CCDS2920

ENSG00000179097

ENSP00000322924

ENST00000319595

EntrezGene:3355

g10835196_3p_at

GE80212

GO:0003674

GO:0004871

GO:0004930

GO:0004993

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0007165

GO:0007186

GO:0007187

GO:0007193

GO:0007267

GO:0007268

GO:0008150

GO:0016020

GO:0016021

GO:0030594

GO:0043167

GO:0051378

GO:0098664

HGNC:5292

HPA005555

HTR1F

HTR1F-201

ILMN_1685285

ILMN_1690949

IPR000276

IPR000450

IPR002231

IPR017452

L04962

L05597

L05597_at

MIM:182134

NM_000866

NM_001322208

NM_001322209

NM_001322210

NP_000857

NP_001309137

NP_001309138

NP_001309139

PF00001

PH_hs_0013159

PR00237

PR00515

PR01101

SM01381

TC03000463.hg

uc062lsi.1

UPI00000503DF

XM_005264751

XM_011533664

XP_005264808

XP_011531966

Participant Of

hasMember

HTR1A,B,D,E,F,HTR5A [plasma membrane]

Inferred To

HTR1F [plasma membrane] (Bos taurus)

HTR1F [plasma membrane] (Canis familiaris)

HTR1F [plasma membrane] (Danio rerio)

HTR1F [plasma membrane] (Gallus gallus)

HTR1F [plasma membrane] (Mus musculus)

HTR1F [plasma membrane] (Rattus norvegicus)

HTR1F [plasma membrane] (Sus scrofa)

HTR1F [plasma membrane] (Taeniopygia guttata)

HTR1F [plasma membrane] (Xenopus tropicalis)

Homologues of HTR1F [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001309138.1, NP_000857.1, NP_001309139.1, XP_005264808.1, XP_011531966.1, NP_001309137.1

ZINC - Metabolites

5HT1F_HUMAN

ZINC - World Drugs

5HT1F_HUMAN

ZINC - FDA approved

5HT1F_HUMAN

ZINC - Substances

5HT1F_HUMAN

GeneCards

P30939

ZINC - Biogenic

5HT1F_HUMAN

ZINC target

P30939

PRO

P30939

ZINC - Predictions - Purchasable

5HT1F_HUMAN

HMDB Protein

HMDBP02464