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HTR2B [plasma membrane]
Stable Identifier
R-HSA-390967
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
5-HT2B receptor, RecName: Full=5-hydroxytryptamine receptor 2B; Short=5-HT-2B; AltName: Full=Serotonin receptor 2B;
GN Name=HTR2B;
OS Homo sapiens, 5HT2B_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HTR2A-C:5HT [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HTR2A-C:5HT [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HTR2A-C:5HT [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HTR2A-C:5HT [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HTR2A-C:5HT [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
5-HT2 receptor can bind serotonin (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
HTR2A-C:5HT [plasma membrane] (Homo sapiens)
HTR2A-C [plasma membrane] (Homo sapiens)
HTR2B [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41595 HTR2B
Gene Names
HTR2B
Chain
chain:1-481
Reference Genes
BioGPS Gene:3357 HTR2B
COSMIC (genes):HTR2B HTR2B
CTD Gene:3357 HTR2B
dbSNP Gene:3357 HTR2B
ENSEMBL:ENSG00000135914 HTR2B
HGNC:5294 HTR2B
KEGG:hsa:3357 HTR2B
Monarch:3357 HTR2B
NCBI Gene:3357 HTR2B
OMIM:601122 HTR2B
UCSC:P41595 HTR2B
Reference Transcript
RefSeq:NM_001320758.1 HTR2B
RefSeq:NM_000867.4 HTR2B
Other Identifiers
11728104_at
16909482
206638_PM_at
206638_at
2603396
2603397
2603398
2603400
2603401
2603403
2603404
2603405
2603406
3357
36245_at
8059680
A_23_P16953
GE60027
GO:0001587
GO:0001755
GO:0001819
GO:0001938
GO:0001965
GO:0003007
GO:0003012
GO:0003013
GO:0003300
GO:0004930
GO:0004993
GO:0005096
GO:0005515
GO:0005654
GO:0005737
GO:0005886
GO:0006874
GO:0006939
GO:0007186
GO:0007187
GO:0007208
GO:0007210
GO:0007268
GO:0007507
GO:0008284
GO:0009410
GO:0010513
GO:0014033
GO:0014827
GO:0016020
GO:0019722
GO:0019934
GO:0023052
GO:0030154
GO:0030425
GO:0030594
GO:0042310
GO:0043005
GO:0043066
GO:0043123
GO:0045202
GO:0048598
GO:0048856
GO:0048870
GO:0050795
GO:0051209
GO:0051378
GO:0051781
GO:0055085
GO:0060089
GO:0070371
GO:0070374
GO:0098664
GO:0098666
GO:0098772
GO:0099589
HMNXSV003046177
ILMN_1735764
PH_hs_0025148
TC02002858.hg
X77307_at
g4504538_3p_at
Participates
as a member of
HTR2A-C [plasma membrane] (Homo sapiens)
Inferred To
5-HT2B [plasma membrane]
(Drosophila melanogaster)
HTR2B [plasma membrane]
(Bos taurus)
HTR2B [plasma membrane]
(Canis familiaris)
HTR2B [plasma membrane]
(Mus musculus)
HTR2B [plasma membrane]
(Rattus norvegicus)
HTR2B [plasma membrane]
(Sus scrofa)
HTR2b [plasma membrane]
(Gallus gallus)
dop-6 [plasma membrane]
(Caenorhabditis elegans)
htr2b [plasma membrane]
(Danio rerio)
htr2b [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000858.3
,
NP_001307687.1
ZINC - World Drugs
5HT2B_HUMAN
Guide to Pharmacology - Targets
7
ENSEMBL
ENSP00000258400
,
ENST00000258400
OpenTargets
ENSG00000135914
ZINC - FDA approved
5HT2B_HUMAN
ZINC - Substances
5HT2B_HUMAN
ZINC - Biogenic
5HT2B_HUMAN
ZINC target
P41595
PRO
P41595
GlyGen
P41595
PDB
7SRR
,
5TVN
,
4IB4
,
6DRZ
,
5TUD
,
7SRS
,
6DRX
,
6DRY
,
7SRQ
,
4NC3
,
6DS0
ZINC - Investigational
5HT2B_HUMAN
ZINC - Metabolites
5HT2B_HUMAN
HPA
ENSG00000135914-HTR2B
Pharos - Targets
P41595
ZINC - Predictions - Purchasable
5HT2B_HUMAN
HMDB Protein
HMDBP02382
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