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HTR6 [plasma membrane]
Stable Identifier
R-HSA-390956
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
5-HT6 receptor, RecName: Full=5-hydroxytryptamine receptor 6; Short=5-HT-6; AltName: Full=Serotonin receptor 6;
GN Name=HTR6;
OS Homo sapiens, 5HT6R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
HTR4,6,7 [plasma membrane] (Homo sapiens)
HTR6 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50406 HTR6
Gene Names
HTR6
Chain
chain:1-440
Reference Genes
BioGPS Gene:3362 HTR6
COSMIC (genes):HTR6 HTR6
CTD Gene:3362 HTR6
dbSNP Gene:3362 HTR6
ENSEMBL:ENSG00000158748 HTR6
HGNC:5301 HTR6
KEGG:hsa:3362 HTR6
Monarch:3362 HTR6
NCBI Gene:3362 HTR6
OMIM:601109 HTR6
UCSC:P50406 HTR6
Reference Transcript
RefSeq:NM_000871.2 HTR6
Other Identifiers
11737248_at
1552857_PM_a_at
1552857_a_at
16660260
206944_PM_at
206944_at
2323787
2323789
2323791
2323792
2323793
2323798
2323799
2323800
32907_at
3362
7898594
A_23_P74766
A_33_P3345016
GE57766
GE84697
GO:0004930
GO:0004969
GO:0004993
GO:0005515
GO:0005886
GO:0005929
GO:0007186
GO:0007187
GO:0007188
GO:0007192
GO:0007268
GO:0016020
GO:0021795
GO:0023052
GO:0030425
GO:0030594
GO:0032008
GO:0043226
GO:0045202
GO:0048870
GO:0060089
GO:0098664
GO:0099589
HMNXSV003010563
Hs.22180.0.S2_3p_at
Hs2.22180.1.S1_3p_s_at
ILMN_1800989
L41147_at
PH_hs_0001935
TC01000251.hg
Participates
as a member of
HTR4,6,7 [plasma membrane] (Homo sapiens)
Inferred To
htr6 [plasma membrane]
(Xenopus tropicalis)
Dop1R1 [plasma membrane]
(Drosophila melanogaster)
HTR6 [plasma membrane]
(Bos taurus)
HTR6 [plasma membrane]
(Canis familiaris)
HTR6 [plasma membrane]
(Gallus gallus)
HTR6 [plasma membrane]
(Mus musculus)
HTR6 [plasma membrane]
(Rattus norvegicus)
HTR6 [plasma membrane]
(Sus scrofa)
dop-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000862.1
Guide to Pharmacology - Targets
11
ENSEMBL
ENST00000289753
,
ENSP00000289753
,
ENSG00000158748
OpenTargets
ENSG00000158748
ZINC - FDA approved
5HT6R_HUMAN
ZINC - Substances
5HT6R_HUMAN
ZINC - Biogenic
5HT6R_HUMAN
ZINC target
P50406
PRO
P50406
PDB
7XTB
,
7YS6
,
8JLZ
ZINC - Investigational
5HT6R_HUMAN
ZINC - Metabolites
5HT6R_HUMAN
GeneCards
HTR6
HPA
ENSG00000158748-HTR6
Pharos - Targets
P50406
ZINC - Predictions - Purchasable
5HT6R_HUMAN
HMDB Protein
HMDBP02713
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
6
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
0.633
7
UniProt:P46821 MAP1B
1
MAP1B(2-2206) [cytosol]
(R-HSA-9836954)
0.581
4
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