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HRH1 [plasma membrane]
Stable Identifier
R-HSA-390908
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Histamine H1 receptor, RecName: Full=Histamine H1 receptor;
GN Name=HRH1;
OS Homo sapiens, HRH1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH1 binds HRH1 inverse agonists (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
HRH1:HRH1 inverse agonists [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
HRH1 binds hist (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35367 HRH1
Gene Names
HRH1
Chain
chain:1-487
Reference Genes
BioGPS Gene:3269 HRH1
COSMIC (genes):HRH1 HRH1
CTD Gene:3269 HRH1
dbSNP Gene:3269 HRH1
ENSEMBL:ENSG00000196639.7 HRH1
HGNC:5182 HRH1
KEGG Gene (Homo sapiens):3269 HRH1
Monarch:3269 HRH1
NCBI Gene:3269 HRH1
OMIM:600167 HRH1
UCSC:P35367 HRH1
Reference Transcript
RefSeq:XM_011533652.1 HRH1
RefSeq:NM_001098211.1 HRH1
RefSeq:NM_001098213.1 HRH1
RefSeq:XM_017006283.1 HRH1
RefSeq:XM_011533653.2 HRH1
RefSeq:XM_017006284.1 HRH1
RefSeq:NM_000861.3 HRH1
RefSeq:NM_001098212.1 HRH1
Other Identifiers
11730363_a_at
11730364_a_at
11737050_x_at
11737051_a_at
16937671
205579_PM_at
205579_at
205580_PM_s_at
205580_s_at
2610717
2610718
2610720
2610721
2610722
2610723
2610724
2610725
2610727
2610729
3269
35384_at
55475_i_at
55477_r_at
71189_at
73483_at
74590_at
8077851
A_14_P200084
A_23_P212179
A_24_P277211
A_33_P3245183
GE60395
GE880763
GO:0002376
GO:0003013
GO:0004930
GO:0004969
GO:0004993
GO:0005829
GO:0005886
GO:0005975
GO:0006954
GO:0007165
GO:0007186
GO:0007187
GO:0007200
GO:0007268
GO:0007613
GO:0008542
GO:0016020
GO:0016021
GO:0023052
GO:0030425
GO:0030594
GO:0032962
GO:0043114
GO:0045202
GO:0045907
GO:0048016
GO:0048167
GO:0048245
GO:0048870
GO:0050877
GO:0050896
GO:0060089
GO:0071420
GO:0098664
HMNXSV003002090
ILMN_1673953
PH_hs_0000211
TC03000064.hg
Z34897_at
g13435403_3p_at
g457654_3p_a_at
Participates
as a component of
HRH1:HRH1 inverse agonists [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
as an input of
HRH1 binds HRH1 inverse agonists (Homo sapiens)
HRH1 binds hist (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
Inferred To
HRH1 [plasma membrane]
(Canis familiaris)
HRH1 [plasma membrane]
(Gallus gallus)
HRH1 [plasma membrane]
(Sus scrofa)
hrh1 [plasma membrane]
(Xenopus tropicalis)
Hrh1 [plasma membrane]
(Mus musculus)
Hrh1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001091682.1
,
XP_016861772.1
,
XP_011531955.1
,
XP_016861773.1
,
NP_001091683.1
,
NP_000852.1
,
NP_001091681.1
,
XP_011531954.1
ZINC - World Drugs
HRH1_HUMAN
Guide to Pharmacology - Targets
262
OpenTargets
ENSG00000196639
ZINC - FDA approved
HRH1_HUMAN
ZINC - Substances
HRH1_HUMAN
ZINC - Biogenic
HRH1_HUMAN
ZINC target
P35367
PRO
P35367
PDB
3RZE
,
7DFL
ZINC - Investigational
HRH1_HUMAN
ZINC - Metabolites
HRH1_HUMAN
HPA
ENSG00000196639-HRH1
GeneCards
P35367
Ensembl
ENST00000431010
,
ENSP00000380247
,
ENSG00000196639
,
ENST00000438284
,
ENSP00000406705
,
ENST00000397056
,
ENSP00000397028
Pharos - Targets
P35367
ZINC - Predictions - Purchasable
HRH1_HUMAN
HMDB Protein
HMDBP02823
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