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HRH2 [plasma membrane]
Stable Identifier
R-HSA-390907
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Histamine H2 receptor, RecName: Full=Histamine H2 receptor; Short=H2R; AltName: Full=Gastric receptor I;
GN Name=HRH2;
OS Homo sapiens, HRH2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH2 binds HRH2 antagonists (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
HRH2:HRH2 antagonists [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
HRH2 binds hist (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25021 HRH2
Gene Names
HRH2
Chain
chain:1-359
Reference Genes
BioGPS Gene:3274 HRH2
COSMIC (genes):HRH2 HRH2
CTD Gene:3274 HRH2
dbSNP Gene:3274 HRH2
ENSEMBL:ENSG00000113749 HRH2
ENSEMBL_homo_sapiens_GENE:ENSG00000113749.8 HRH2
HGNC:5183 HRH2
KEGG Gene (Homo sapiens):3274 HRH2
Monarch:3274 HRH2
NCBI Gene:3274 HRH2
OMIM:142703 HRH2
UCSC:P25021 HRH2
Reference Transcript
RefSeq:NM_022304.2 HRH2
RefSeq:NM_001131055.1 HRH2
Other Identifiers
11738252_at
11740951_s_at
16992664
220805_PM_at
220805_at
2842158
2842159
2842160
2842162
2842163
2842166
2842167
3274
8110106
A_14_P104468
A_23_P7535
GE62662
GO:0001696
GO:0002376
GO:0003013
GO:0004930
GO:0004969
GO:0004993
GO:0005886
GO:0006955
GO:0007165
GO:0007186
GO:0007187
GO:0007268
GO:0016020
GO:0022600
GO:0023052
GO:0030425
GO:0030594
GO:0045202
GO:0045907
GO:0060089
GO:0098664
HMNXSV003007575
HMNXSV003048998
ILMN_1722411
PH_hs_0013124
TC05000981.hg
Participates
as a component of
HRH2:HRH2 antagonists [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
as an input of
HRH2 binds HRH2 antagonists (Homo sapiens)
HRH2 binds hist (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
Inferred To
5-HT1B [plasma membrane]
(Drosophila melanogaster)
Hrh2 [plasma membrane]
(Mus musculus)
Hrh2 [plasma membrane]
(Rattus norvegicus)
5-HT1A [plasma membrane]
(Drosophila melanogaster)
ser-4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of HRH2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of HRH2 [plasma membrane]
(Drosophila melanogaster)
Homologues of HRH2 [plasma membrane]
(Rattus norvegicus)
si:dkey-179g5.13 [plasma membrane]
(Danio rerio)
hrh2 [plasma membrane]
(Xenopus tropicalis)
HRH2 [plasma membrane]
(Bos taurus)
HRH2 [plasma membrane]
(Canis familiaris)
HRH2 [plasma membrane]
(Gallus gallus)
HRH2 [plasma membrane]
(Sus scrofa)
dop-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001124527.1
,
NP_071640.1
ZINC - World Drugs
HRH2_HUMAN
Guide to Pharmacology - Targets
263
OpenTargets
ENSG00000113749
ZINC - FDA approved
HRH2_HUMAN
ZINC - Substances
HRH2_HUMAN
ZINC - Biogenic
HRH2_HUMAN
ZINC target
P25021
PRO
P25021
PDB
7UL3
ZINC - Investigational
HRH2_HUMAN
ZINC - Metabolites
HRH2_HUMAN
HPA
ENSG00000113749-HRH2
GeneCards
P25021
Ensembl
ENST00000377291
,
ENSP00000366506
,
ENSG00000113749
Pharos - Targets
P25021
ZINC - Predictions - Purchasable
HRH2_HUMAN
HMDB Protein
HMDBP02157
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