D2D3,4 bind to DA

Stable Identifier
R-HSA-390846
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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D2D3,4 bind to DA
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Dopamine receptors 3 (Giros et al. 1990) and 4 (Van Tol et al. 1991) are members of the D2-like dopamine receptor family. Once activated, these receptors couple with the G protein alpha-i subtype which directly inhibits cAMP formation by inhibition of the enzyme adeylate cyclase.

Literature References
PubMed ID Title Journal Year
1840645 Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

Van Tol, HH, Bunzow, JR, Guan, HC, Sunahara, RK, Seeman, P, Niznik, HB, Civelli, O

Nature 1991
2129115 [Gene cloning of human dopaminergic D3 receptor and identification of its chromosome]

Giros, B, Martres, MP, Sokoloff, P, Schwartz, JC

C R Acad Sci III 1990
Participants
Input
Output
Participant Of
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Authored
Jassal, B  (2009-02-10)
Reviewed
D'Eustachio, P  (2009-03-02)
Created
Jassal, B  (2009-02-10)