Reactome | D2D3,4 bind to DA

D2D3,4 bind to DA

Stable Identifier

R-HSA-390846

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Dopamine receptors (Homo sapiens)
        
        D2D3,4 bind to DA (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dopamine receptors 3 (Giros et al. 1990) and 4 (Van Tol et al. 1991) are members of the D2-like dopamine receptor family. Once activated, these receptors couple with the G protein alpha-i subtype which directly inhibits cAMP formation by inhibition of the enzyme adeylate cyclase.

Literature References

PubMed ID	Title	Journal	Year
1840645	Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine Van Tol, HH, Bunzow, JR, Guan, HC, Sunahara, RK, Seeman, P, Niznik, HB, Civelli, O	Nature	1991
2129115	[Gene cloning of human dopaminergic D3 receptor and identification of its chromosome] Giros, B, Martres, MP, Sokoloff, P, Schwartz, JC	C R Acad Sci III	1990