Reactome | D2D3,4 bind to DA

D2D3,4 bind to DA

Stable Identifier

R-HSA-390846

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Dopamine receptors (Homo sapiens)
        
        D2D3,4 bind to DA (Homo sapiens)

General

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Dopamine receptors 3 (Giros et al. 1990) and 4 (Van Tol et al. 1991) are members of the D2-like dopamine receptor family. Once activated, these receptors couple with the G protein alpha-i subtype which directly inhibits cAMP formation by inhibition of the enzyme adeylate cyclase.

Literature References

PubMed ID	Title	Journal	Year
2129115	[Gene cloning of human dopaminergic D3 receptor and identification of its chromosome] Martres, MP, Schwartz, JC, Giros, B, Sokoloff, P	C R Acad Sci III	1990
1840645	Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine Seeman, P, Sunahara, RK, Bunzow, JR, Van Tol, HH, Niznik, HB, Civelli, O, Guan, HC	Nature	1991