Reactome | p-S16-MYLPF [cytosol]

p-S16-MYLPF [cytosol]

Stable Identifier

R-HSA-390744

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S16-MLRS, Phosphorylated Myosin regulatory light chain 2, skeletal muscle isoform

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
    - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
  - Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
    - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
      - p-S16-MYLPF [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S16-MYLPF [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96A32 MYL11

Gene Names

MYL11, HSRLC, MYLPF

Chain

initiator methionine:1, chain:2-169

Reference Genes

BioGPS Gene:29895 MYL11

CTD Gene:29895 MYL11

dbSNP Gene:29895 MYL11

ENSEMBL:ENSG00000180209 MYLPF

ENSEMBL:ENSG00000180209.12 MYL11

HGNC:29824 MYL11

KEGG Gene (Homo sapiens):29895 MYL11

Monarch:29895 MYL11

NCBI Gene:29895 MYL11

OMIM:617378 MYL11

UCSC:Q96A32 MYL11

Reference Transcript

Other Identifiers

11721252_a_at

11721253_at

16817860

205163_PM_at

205163_at

29895

34881_at

3656156

3656157

3656160

3656161

3656162

3656164

3656166

3656168

3656169

3656170

7994804

A_23_P60742

GE61453

GE81815

GO:0002376

GO:0003012

GO:0005198

GO:0005509

GO:0005515

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005856

GO:0005859

GO:0006936

GO:0006955

GO:0007519

GO:0008307

GO:0016459

GO:0033275

GO:0043226

GO:0046872

GO:0048856

GO:0060415

HMNXSV003014148

M21812_at

TC16000345.hg

g7019426_3p_at

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

Other forms of this molecule

MYLPF [cytosol]

Inferred To

Homologues of p-S16-MYLPF [cytosol] (Caenorhabditis elegans)

Homologues of p-S16-MYLPF [cytosol] (Drosophila melanogaster)

Homologues of p-S16-MYLPF [cytosol] (Plasmodium falciparum)

phospho-CT39356 [cytosol] (Drosophila melanogaster)

phospho-p-S16-MYLPF [cytosol] (Bos taurus)

phospho-p-S16-MYLPF [cytosol] (Caenorhabditis elegans)

phospho-p-S16-MYLPF [cytosol] (Canis familiaris)

phospho-p-S16-MYLPF [cytosol] (Danio rerio)

phospho-p-S16-MYLPF [cytosol] (Drosophila melanogaster)

phospho-p-S16-MYLPF [cytosol] (Mus musculus)

phospho-p-S16-MYLPF [cytosol] (Plasmodium falciparum)

phospho-p-S16-MYLPF [cytosol] (Rattus norvegicus)

phospho-p-S16-MYLPF [cytosol] (Saccharomyces cerevisiae)

phospho-p-S16-MYLPF [cytosol] (Schizosaccharomyces pombe)

phospho-MYL11 [cytosol] (Sus scrofa)

phospho-mlcR [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 16

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001311387.1, NP_037424.2, NP_001311388.1

GeneCards

Q96A32

HPA

ENSG00000180209-MYL11

Ensembl

ENSG00000180209, ENST00000322861, ENSP00000325239

PRO

Q96A32

Pharos - Targets

Q96A32

HMDB Protein

HMDBP07799

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3