Reactome | p-S23-MYL7 [cytosol]

p-S23-MYL7 [cytosol]

Stable Identifier

R-HSA-390732

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated Myosin regulatory light chain 2, atrial isoform

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
    - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
  - Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
    - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
      - p-S23-MYL7 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S23-MYL7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01449 MYL7

Gene Names

MYL7, MYL2A, MYLC2A

Chain

initiator methionine:, chain:2-175

Reference Genes

BioGPS Gene:58498 MYL7

COSMIC (genes):MYL7 MYL7

CTD Gene:58498 MYL7

dbSNP Gene:58498 MYL7

ENSEMBL:ENSG00000106631 MYL7

HGNC:21719 MYL7

KEGG:hsa:58498 MYL7

Monarch:58498 MYL7

NCBI Gene:58498 MYL7

OMIM:613993 MYL7

UCSC:Q01449 MYL7

Reference Transcript

RefSeq:NM_021223.2 MYL7

Other Identifiers

11723000_at

17057202

219942_PM_at

219942_at

3048448

3048449

3048450

3048451

3048452

3048453

3048454

3048455

3048456

3048457

3048458

3048459

3048460

3048461

3048462

36662_at

58498

8139307

88149_f_at

88153_r_at

A_23_P59738

GE79426

GO:0003013

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0016459

GO:0030016

GO:0031672

GO:0043197

GO:0043226

GO:0046872

GO:0048738

GO:0048856

GO:0060047

HMNXSV003044642

HMNXSV003045504

ILMN_1681857

M94547_at

TC07001336.hg

g10864036_3p_at

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

Other forms of this molecule

MYL7 [cytosol]

Inferred To

phospho-p-S23-MYL7 [cytosol] (Caenorhabditis elegans)

phospho-p-S23-MYL7 [cytosol] (Drosophila melanogaster)

phospho-p-S23-MYL7 [cytosol] (Mus musculus)

phospho-p-S23-MYL7 [cytosol] (Plasmodium falciparum)

phospho-p-S23-MYL7 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S23-MYL7 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S23-MYL7 [cytosol] (Sus scrofa)

phospho-Myl7 [cytosol] (Rattus norvegicus)

phospho-CT39356 [cytosol] (Drosophila melanogaster)

Homologues of p-S23-MYL7 [cytosol] (Caenorhabditis elegans)

Homologues of p-S23-MYL7 [cytosol] (Drosophila melanogaster)

Homologues of p-S23-MYL7 [cytosol] (Plasmodium falciparum)

phospho-myl7 [cytosol] (Danio rerio)

phospho-MYL7 [cytosol] (Bos taurus)

phospho-MYL7 [cytosol] (Canis familiaris)

phospho-mlcR [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 23

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ENSEMBL

ENST00000223364, ENSP00000223364, ENSG00000106631

OpenTargets

ENSG00000106631

GeneCards

MYL7

HPA

ENSG00000106631-MYL7

PRO

Q01449

Pharos - Targets

Q01449

HMDB Protein

HMDBP07798