Reactome | MYL12B [cytosol]

MYL12B [cytosol]

Stable Identifier

R-HSA-390727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MYLC2B, Myosin regulatory light chain 2-B, smooth muscle isoform, MRLC2_HUMAN

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)
        
        MYL12B [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)
        
        MYL12B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14950 MYL12B

Gene Names

MYL12B, MRLC2, MYLC2B

Chain

chain:1-172

Reference Genes

BioGPS Gene:103910 MYL12B

BioGPS Gene:10627 MYL12B

COSMIC (genes):MYL12B MYL12B

CTD Gene:103910 MYL12B

CTD Gene:10627 MYL12B

dbSNP Gene:103910 MYL12B

dbSNP Gene:10627 MYL12B

ENSEMBL:ENSG00000118680 MYL12B

HGNC:29827 MYL12B

KEGG:hsa:103910 MYL12B

Monarch:103910 MYL12B

Monarch:10627 MYL12B

NCBI Gene:103910 MYL12B

NCBI Gene:10627 MYL12B

UCSC:O14950 MYL12B

Reference Transcript

Other Identifiers

103910

11744197_s_at

16850616

201318_PM_s_at

201318_s_at

221474_PM_at

221474_at

2796323

3591070

3776439

3776443

3776450

3776451

3776452

3776453

3776454

3776455

3776458

3776459

3776460

3776461

3776462

3776463

41187_at

63986_at

8019930

A_32_P42925

GE61295

GO:0001725

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0005903

GO:0005938

GO:0008092

GO:0008360

GO:0016459

GO:0016460

GO:0030016

GO:0030018

GO:0032036

GO:0032991

GO:0043226

GO:0045177

GO:0046872

GO:0070062

HMNXSV003024931

ILMN_1654016

ILMN_1725204

PH_hs_0026604

TC18000017.hg

g829622_3p_at

g829622_3p_x_at

Participates

as a member of

Other forms of this molecule

p-T19-MYL12B [cytosol]

p-T19,S20-MYL12B [cytosol]

Inferred To

mlcR [cytosol] (Dictyostelium discoideum)

MYL12B [cytosol] (Bos taurus)

MYL12B [cytosol] (Caenorhabditis elegans)

MYL12B [cytosol] (Canis familiaris)

MYL12B [cytosol] (Drosophila melanogaster)

MYL12B [cytosol] (Gallus gallus)

MYL12B [cytosol] (Mus musculus)

MYL12B [cytosol] (Plasmodium falciparum)

MYL12B [cytosol] (Rattus norvegicus)

MYL12B [cytosol] (Saccharomyces cerevisiae)

MYL12B [cytosol] (Schizosaccharomyces pombe)

MYL12B [cytosol] (Sus scrofa)

Homologues of MYL12B [cytosol] (Gallus gallus)

myl12b [cytosol] (Xenopus tropicalis)

myl12.2 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001138416.1, NP_001289978.1, NP_001138417.1, NP_291024.1

ENSEMBL

ENST00000648965, ENSP00000464464, ENSP00000383037, ENSP00000237500, ENST00000400175, ENSP00000463559, ENSP00000496809, ENST00000237500, ENST00000581193, ENST00000584539

OpenTargets

ENSG00000118680

HPA

ENSG00000118680-MYL12B

PRO

O14950

Pharos - Targets

O14950

GlyGen

O14950

HMDB Protein

HMDBP07817

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.537	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	3