Reactome | ADRA2A,B,C bind ADR,NAd

ADRA2A,B,C bind ADR,NAd

Stable Identifier

R-HSA-390663

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Alpha-2 adrenoceptors bind catecholamines

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Adrenoceptors (Homo sapiens)
        
        ADRA2A,B,C bind ADR,NAd (Homo sapiens)

General

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Alpha-2 adrenoceptors couple with G protein alpha-i subtype which decreases adenylyl cyclase activity, thus reducing cAMP intracellular levels resulting in smooth muscle contraction. There are three alpha-2 subtypes in humans; 2A (Kobilka BK et al, 1987), 2B (Weinshank RL et al, 1990) and 2C (Hirasawa A et al, 1993).

Literature References

PubMed ID	Title	Journal	Year
8396931	Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor Hirasawa, A, Horie, K, Tanaka, T, Takagaki, K, Murai, M, Yano, J, Tsujimoto, G	Biochem Biophys Res Commun	1993
2823383	Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Kobilka, BK, Matsui, H, Kobilka, TS, Yang-Feng, TL, Francke, U, Caron, MG, Lefkowitz, RJ, Regan, JW	Science	1987
2172775	Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor Weinshank, RL, Zgombick, JM, Macchi, M, Adham, N, Lichtblau, H, Branchek, TA, Hartig, PR	Mol Pharmacol	1990