Reactome | ADRA2A,B,C bind ADR,NAd

ADRA2A,B,C bind ADR,NAd

Stable Identifier

R-HSA-390663

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Alpha-2 adrenoceptors bind catecholamines

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Adrenoceptors (Homo sapiens)
        
        ADRA2A,B,C bind ADR,NAd (Homo sapiens)

General

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Alpha-2 adrenoceptors couple with G protein alpha-i subtype which decreases adenylyl cyclase activity, thus reducing cAMP intracellular levels resulting in smooth muscle contraction. There are three alpha-2 subtypes in humans; 2A (Kobilka BK et al, 1987), 2B (Weinshank RL et al, 1990) and 2C (Hirasawa A et al, 1993).

Literature References

PubMed ID	Title	Journal	Year
2823383	Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Kobilka, BK, Matsui, H, Kobilka, TS, Yang-Feng, TL, Francke, U, Caron, MG, Lefkowitz, RJ, Regan, JW	Science	1987
8396931	Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor Hirasawa, A, Horie, K, Tanaka, T, Takagaki, K, Murai, M, Yano, J, Tsujimoto, G	Biochem Biophys Res Commun	1993
2172775	Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor Weinshank, RL, Zgombick, JM, Macchi, M, Adham, N, Lichtblau, H, Branchek, TA, Hartig, PR	Mol Pharmacol	1990

Participants

Input

Output

ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

Orthologous Events

ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)

ADRA2A,B,C bind ADR,NAd (Canis familiaris)

ADRA2A,B,C bind ADR,NAd (Danio rerio)

ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)

ADRA2A,B,C bind ADR,NAd (Gallus gallus)

ADRA2A,B,C bind ADR,NAd (Mus musculus)

ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)

ADRA2A,B,C bind ADR,NAd (Sus scrofa)

ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)

Authored

Jassal, B (2009-02-10)

Reviewed

D'Eustachio, P (2009-03-02)

Created

Jassal, B (2009-02-10)