Reactome | ADRA2A,B,C bind ADR,NAd

ADRA2A,B,C bind ADR,NAd

Stable Identifier

R-HSA-390663

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Alpha-2 adrenoceptors bind catecholamines

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Adrenoceptors (Homo sapiens)
        
        ADRA2A,B,C bind ADR,NAd (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Alpha-2 adrenoceptors couple with G protein alpha-i subtype which decreases adenylyl cyclase activity, thus reducing cAMP intracellular levels resulting in smooth muscle contraction. There are three alpha-2 subtypes in humans; 2A (Kobilka BK et al, 1987), 2B (Weinshank RL et al, 1990) and 2C (Hirasawa A et al, 1993).

Literature References

PubMed ID	Title	Journal	Year
8396931	Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor Hirasawa, A, Takagaki, K, Murai, M, Horie, K, Tanaka, T, Tsujimoto, G, Yano, J	Biochem Biophys Res Commun	1993
2823383	Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Regan, JW, Caron, MG, Lefkowitz, RJ, Matsui, H, Yang-Feng, TL, Kobilka, TS, Kobilka, BK, Francke, U	Science	1987
2172775	Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor Lichtblau, H, Weinshank, RL, Macchi, M, Branchek, TA, Hartig, PR, Adham, N, Zgombick, JM	Mol Pharmacol	1990