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ADRA2B [plasma membrane]
Stable Identifier
R-HSA-390659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha-2B adrenoceptor, RecName: Full=Alpha-2B adrenergic receptor; AltName: Full=Alpha-2B adrenoreceptor; AltName: Full=Alpha-2B adrenoceptor; AltName: Full=Alpha-2 adrenergic receptor subtype C2;
GN Name=ADRA2B; Synonyms=ADRA2L1, ADRA2RL1;
OS Homo sapiens, ADA2B_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Adrenaline signalling through Alpha-2 adrenergic receptor (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gz complex dissociates (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
α2-agonists bind ADRA2A,B,C (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
α2-agonists:ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2B [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18089 ADRA2B
Gene Names
ADRA2B, ADRA2L1, ADRA2RL1
Chain
chain:1-450
Reference Genes
BioGPS Gene:151 ADRA2B
COSMIC (genes):ADRA2B ADRA2B
CTD Gene:151 ADRA2B
dbSNP Gene:151 ADRA2B
ENSEMBL:ENSG00000274286 ADRA2B
HGNC:282 ADRA2B
KEGG:hsa:151 ADRA2B
Monarch:151 ADRA2B
NCBI Gene:151 ADRA2B
OMIM:104260 ADRA2B
UCSC:P18089 ADRA2B
Reference Transcript
RefSeq:NM_000682.6 ADRA2B
Other Identifiers
11737497_at
151
16900425
208544_PM_at
208544_at
2565084
2565085
2565086
2565087
2565088
2565089
2565090
2565091
2565092
2565096
8053869
90674_at
A_23_P378926
GE778106
GO:0000165
GO:0001525
GO:0003013
GO:0003056
GO:0004930
GO:0004935
GO:0004938
GO:0005515
GO:0005829
GO:0005886
GO:0006940
GO:0007186
GO:0007267
GO:0007565
GO:0009986
GO:0010700
GO:0016020
GO:0019229
GO:0022414
GO:0023052
GO:0030168
GO:0032148
GO:0032811
GO:0035624
GO:0043226
GO:0043231
GO:0043410
GO:0045666
GO:0045777
GO:0051379
GO:0060089
GO:0070474
GO:0071875
GO:0071880
HMNXSV003021615
ILMN_1677868
M34041_at
PH_hs_0013103
TC02002100.hg
g4501964_3p_at
Participates
as a member of
ADRA2A,B,C [plasma membrane] (Homo sapiens)
Inferred To
tyra-2 [plasma membrane]
(Caenorhabditis elegans)
Adra2b [plasma membrane]
(Mus musculus)
Adra2b [plasma membrane]
(Rattus norvegicus)
adra2b [plasma membrane]
(Danio rerio)
adra2b [plasma membrane]
(Xenopus tropicalis)
Homologues of ADRA2A [plasma membrane]
(Caenorhabditis elegans)
Oct-TyrR [plasma membrane]
(Drosophila melanogaster)
Octalpha2R [plasma membrane]
(Drosophila melanogaster)
Homologues of ADRA2B [plasma membrane]
(Drosophila melanogaster)
ser-2 [plasma membrane]
(Caenorhabditis elegans)
ADRA2B [plasma membrane]
(Bos taurus)
ADRA2B [plasma membrane]
(Canis familiaris)
ADRA2B [plasma membrane]
(Gallus gallus)
ADRA2B [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000673.2
ZINC - World Drugs
ADA2B_HUMAN
Guide to Pharmacology - Targets
26
ENSEMBL
ENSP00000480573
,
ENST00000620793
OpenTargets
ENSG00000274286
ZINC - FDA approved
ADA2B_HUMAN
ZINC - Substances
ADA2B_HUMAN
ZINC - Biogenic
ADA2B_HUMAN
ZINC target
P18089
PRO
P18089
PDB
6K41
,
6K42
ZINC - Investigational
ADA2B_HUMAN
ZINC - Metabolites
ADA2B_HUMAN
HPA
ENSG00000274286-ADRA2B
Pharos - Targets
P18089
Orphanet
ADRA2B
ZINC - Predictions - Purchasable
ADA2B_HUMAN
HMDB Protein
HMDBP01602
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