Reactome | CHRM1,3,5 bind acetylcholine

CHRM1,3,5 bind acetylcholine

Stable Identifier

R-HSA-390649

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        CHRM1,3,5 bind acetylcholine (Homo sapiens)

General

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The M1 receptor (Peralta EG et al, 1987) is found in exocrine glands and the CNS. It mediates slow excitatory postsynaptic potential (EPSP) at the ganglion in the postganglionic nerve. The M3 receptor (Peralta EG et al, 1987) is found in smooth muscle of the blood vessels and in the lungs. M3 mediates vascular relaxation (by activating vascular endothelial cells causing increased NO synthesis) and lung constriction (by coupling to Gq protein causing increased intracellular calcium). The location of the M5 receptor is not well known but thought to be in the CNS.
All of these three receptors couple with Gq/11 protein which use the upregulation of phospholipase C and therefore inositol trisphosphate and intracellular calcium as a signaling mechanism (Bräuner-Osborne H and Brann MR, 1996).

Literature References

PubMed ID	Title	Journal	Year
3443095	Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors Capon, DJ, Winslow, JW, Peralta, EG, Smith, DH, Ramachandran, J, Ashkenazi, A	EMBO J	1987
8925880	Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells Brauner-Osborne, H, Brann, MR	Eur J Pharmacol	1996
3272174	Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes Buckley, NJ, Young, AC, Bonner, TI, Brann, MR	Neuron	1988