CHRM1,3,5 bind acetylcholine

Stable Identifier
Reaction [binding]
Homo sapiens
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The M1 receptor (Peralta EG et al, 1987) is found in exocrine glands and the CNS. It mediates slow excitatory postsynaptic potential (EPSP) at the ganglion in the postganglionic nerve. The M3 receptor (Peralta EG et al, 1987) is found in smooth muscle of the blood vessels and in the lungs. M3 mediates vascular relaxation (by activating vascular endothelial cells causing increased NO synthesis) and lung constriction (by coupling to Gq protein causing increased intracellular calcium). The location of the M5 receptor is not well known but thought to be in the CNS.
All of these three receptors couple with Gq/11 protein which use the upregulation of phospholipase C and therefore inositol trisphosphate and intracellular calcium as a signaling mechanism (Bräuner-Osborne H and Brann MR, 1996).

Literature References
PubMed ID Title Journal Year
3443095 Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors

Capon, DJ, Winslow, JW, Peralta, EG, Smith, DH, Ramachandran, J, Ashkenazi, A

EMBO J 1987
8925880 Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells

Brauner-Osborne, H, Brann, MR

Eur J Pharmacol 1996
3272174 Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

Buckley, NJ, Young, AC, Bonner, TI, Brann, MR

Neuron 1988
Orthologous Events
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