The alpha-1 adrenoceptors are involved in smooth muscle contraction. This is achieved by the receptor-ligand complex coupling with the G protein alpha-q/11 subtype, which results in increased intracellular calcium and thus muscle contraction. There are 3 subtypes of the alpha-1 adrenoceptor; 1a (Hirasawa A et al, 1993), 1b (Ramarao CS et al, 1992) and 1d (Esbenshade TA et al, 1995).
Hirasawa, A, Takagaki, K, Murai, M, Horie, K, Tanaka, T, Tsujimoto, G, Yano, J
Hirasawa, A, Murphy, TJ, Esbenshade, TA, Minneman, KP, Tanaka, T, Yano, J, Tsujimoto, G
Ramarao, CS, Riek, RP, Denker, JM, Graham, RM, Gaivin, RJ, Perez, DM
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