Reactome | ADRA1A,B,D bind ADR,NAd

ADRA1A,B,D bind ADR,NAd

Stable Identifier

R-HSA-390641

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Alpha-1 adrenoceptors bind catecholamines

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Adrenoceptors (Homo sapiens)
        
        ADRA1A,B,D bind ADR,NAd (Homo sapiens)

General

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The alpha-1 adrenoceptors are involved in smooth muscle contraction. This is achieved by the receptor-ligand complex coupling with the G protein alpha-q/11 subtype, which results in increased intracellular calcium and thus muscle contraction. There are 3 subtypes of the alpha-1 adrenoceptor; 1a (Hirasawa A et al, 1993), 1b (Ramarao CS et al, 1992) and 1d (Esbenshade TA et al, 1995).

Literature References

PubMed ID	Title	Journal	Year
7746284	Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells Esbenshade, TA, Hirasawa, A, Tsujimoto, G, Tanaka, T, Yano, J, Minneman, KP, Murphy, TJ	Mol Pharmacol	1995
8396931	Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor Hirasawa, A, Horie, K, Tanaka, T, Takagaki, K, Murai, M, Yano, J, Tsujimoto, G	Biochem Biophys Res Commun	1993
1328250	Genomic organization and expression of the human alpha 1B-adrenergic receptor Ramarao, CS, Denker, JM, Perez, DM, Gaivin, RJ, Riek, RP, Graham, RM	J Biol Chem	1992