The alpha-1 adrenoceptors are involved in smooth muscle contraction. This is achieved by the receptor-ligand complex coupling with the G protein alpha-q/11 subtype, which results in increased intracellular calcium and thus muscle contraction. There are 3 subtypes of the alpha-1 adrenoceptor; 1a (Hirasawa A et al, 1993), 1b (Ramarao CS et al, 1992) and 1d (Esbenshade TA et al, 1995).
Esbenshade, TA, Hirasawa, A, Tsujimoto, G, Tanaka, T, Yano, J, Minneman, KP, Murphy, TJ
Hirasawa, A, Horie, K, Tanaka, T, Takagaki, K, Murai, M, Yano, J, Tsujimoto, G
Ramarao, CS, Denker, JM, Perez, DM, Gaivin, RJ, Riek, RP, Graham, RM
© 2021 Reactome
