Reactome | TNNT1 [cytosol]

TNNT1 [cytosol]

Stable Identifier

R-HSA-390544

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Troponin T, slow skeletal muscle, TNNT1_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin T [cytosol] (Homo sapiens)
        
        TNNT1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P13805 TNNT1

Gene Names

TNNT1, TNT

Chain

chain:1-278

Reference Genes

BioGPS Gene:7138 TNNT1

COSMIC (genes):TNNT1 TNNT1

CTD Gene:7138 TNNT1

dbSNP Gene:7138 TNNT1

ENSEMBL:ENSG00000105048 TNNT1

HGNC:11948 TNNT1

KEGG:hsa:7138 TNNT1

Monarch:7138 TNNT1

NCBI Gene:7138 TNNT1

OMIM:191041 TNNT1

UCSC:P13805 TNNT1

Reference Transcript

Participates

as a member of

Troponin T [cytosol] (Homo sapiens)

Inferred To

TNNT1 [cytosol] (Bos taurus)

TNNT1 [cytosol] (Canis familiaris)

TNNT1 [cytosol] (Gallus gallus)

TNNT1 [cytosol] (Sus scrofa)

Tnnt1 [cytosol] (Mus musculus)

Tnnt1 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000356783, ENSG00000105048, ENST00000588981, ENSP00000291901, ENSP00000467176, ENSP00000349233, ENST00000587758, ENST00000291901, ENSP00000467789

OpenTargets

ENSG00000105048

GeneCards

TNNT1

HPA

ENSG00000105048-TNNT1

PRO

P13805

Pharos - Targets

P13805

Orphanet

TNNT1

HMDB Protein

HMDBP08062

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.666	4
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.666	4
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.553	2