Folding of actin by CCT/TriC

Stable Identifier
R-HSA-390450
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Pathway
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Homo sapiens
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Nucleotide-independent transfer of beta-actin from prefoldin to CCT occurs when prefoldin binds to CCT (Vainberg et al., 1998). Following ATP- dependent folding within CCT (Gao et al., 1992), beta-actin is released as a soluble, monomeric protein.

Literature References
PubMed ID Title Journal Year
8104191 Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin

Melki, R, Cowan, NJ, Chow, RL, Vainberg, IE

J Cell Biol 1993
9630229 Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin

Klein, HL, Rommelaere, H, Vandekerckhove, J, Lewis, SA, Cowan, NJ, Ampe, C, Vainberg, IE

Cell 1998
1351421 A cytoplasmic chaperonin that catalyzes beta-actin folding

Cowan, NJ, Chow, RL, Thomas, JO, Gao, Y, Lee, GH

Cell 1992
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