FAR2 reduces PalmCoA to HXOL

Stable Identifier
R-HSA-390438
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2]
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FAR2 reduces PalmCoA to HXOL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxisomal fatty acyl-CoA reductase 2 (FAR2) catalyzes the reaction of palmitoyl-CoA (PalmCoA) and 2 NADPH + 2 H+ to form hexadecanol (HXOL), CoASH, and 2 NADP+. As judged from mRNA levels, FAR2 is not widely expressed in the body but is abundant in brain (Cheng and Russell 2004).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity of FAR2 [peroxisomal membrane]
Physical Entity
FAR2 [peroxisomal membrane]
Activity
oxidoreductase activity (0016491)
Orthologous Events
FAR2 reduces PalmCoA to HXOL (Bos taurus)
FAR2 reduces PalmCoA to HXOL (Caenorhabditis elegans)
FAR2 reduces PalmCoA to HXOL (Canis familiaris)
FAR2 reduces PalmCoA to HXOL (Danio rerio)
FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)
FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)
FAR2 reduces PalmCoA to HXOL (Gallus gallus)
FAR2 reduces PalmCoA to HXOL (Mus musculus)
FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)
FAR2 reduces PalmCoA to HXOL (Sus scrofa)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-03-16)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-02-07)