1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

Stable Identifier
R-HSA-390427
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxisomal alkylglycerone phosphate synthase (AGPS) catalyzes the reaction of 1-palmitoylglycerone phosphate and hexadecanol to form O-hexadecylglycerone phosphate and palmitate. The active form of the enzyme is post-translationally cleaved to remove its 58 aminoterminal residues, has a molecule of FAD as a cofactor, and occurs in the peroxisome as a complex with glyceronephosphate O-acyltransferase (GNPAT) (Biermann et al. 1999; Bierman and van den Bosch 1999; de Vet et al. 2000).

Literature References
PubMed ID Title Journal Year
10215861 Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes

Biermann, J, Just, WW, Wanders, RJ, van den Bosch, H

Eur J Biochem 1999
10415121 In vitro processing of the human alkyl-dihydroxyacetonephosphate synthase precursor

Biermann, J, van den Bosch, H

Arch Biochem Biophys 1999
10692424 Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide

de Vet, EC, Hilkes, YH, Fraaije, MW, van den Bosch, H

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alkylglycerone-phosphate synthase activity of GNPAT:AGPS complex [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created