Reactome | 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

Stable Identifier

R-HSA-390427

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxisomal alkylglycerone phosphate synthase (AGPS) catalyzes the reaction of 1-palmitoylglycerone phosphate and hexadecanol to form O-hexadecylglycerone phosphate and palmitate. The active form of the enzyme is post-translationally cleaved to remove its 58 aminoterminal residues, has a molecule of FAD as a cofactor, and occurs in the peroxisome as a complex with glyceronephosphate O-acyltransferase (GNPAT) (Biermann et al. 1999; Bierman and van den Bosch 1999; de Vet et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10415121	In vitro processing of the human alkyl-dihydroxyacetonephosphate synthase precursor Biermann, J, van den Bosch, H	Arch Biochem Biophys	1999
10215861	Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes Biermann, J, Just, WW, Wanders, RJA, van den Bosch, H	Eur J Biochem	1999
10692424	Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide de Vet, EC, Hilkes, YH, Fraaije, MW, van den Bosch, H	J Biol Chem	2000