Reactome | 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

Stable Identifier

R-HSA-390427

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

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1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

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Peroxisomal alkylglycerone phosphate synthase (AGPS) catalyzes the reaction of 1-palmitoylglycerone phosphate and hexadecanol to form O-hexadecylglycerone phosphate and palmitate. The active form of the enzyme is post-translationally cleaved to remove its 58 aminoterminal residues, has a molecule of FAD as a cofactor, and occurs in the peroxisome as a complex with glyceronephosphate O-acyltransferase (GNPAT) (Biermann et al. 1999; Bierman and van den Bosch 1999; de Vet et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10415121	In vitro processing of the human alkyl-dihydroxyacetonephosphate synthase precursor Biermann, J, van den Bosch, H	Arch Biochem Biophys	1999
10215861	Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes Biermann, J, Just, WW, van den Bosch, H, Wanders, RJA	Eur J Biochem	1999
10692424	Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide van den Bosch, H, de Vet, EC, Hilkes, YH, Fraaije, MW	J Biol Chem	2000