Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D

Stable Identifier
Reaction [binding]
Homo sapiens
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Beta-tubulin folding intermediates generated via ATP-dependent interaction with TriC/CCT are captured by tubulin-specific chaperones A and D (TBCA and TBCD) (Tian et al. 1996, Tian et al. 1997) in a reversible reaction forming tubulin intermediate/cofactor complexes Factor A:beta tubulin or Factor D:beta tubulin. TBCD is involved in the tubulin-folding pathway, acting as a GTPase activating protein (GAP) for beta-tubulin. The ADP-ribosylation factor-like protein 2 (ARL2) is able to down-regulate TBCD specifically, thus preventing microtuble disruption (Bhamidipati et al. 2000, Tian et al. 2010).

Literature References
PubMed ID Title Journal Year
10831612 ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin

Lewis, SA, Cowan, NJ, Bhamidipati, A

J. Cell Biol. 2000
20740604 Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity

Cowan, NJ, Tian, G, Thomas, S

Cytoskeleton (Hoboken) 2010
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