Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D

Stable Identifier
R-HSA-389969
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Beta-tubulin folding intermediates generated via ATP-dependent interaction with TriC/CCT are captured by tubulin-specific chaperones A and D (TBCA and TBCD) (Tian et al. 1996, Tian et al. 1997) in a reversible reaction forming tubulin intermediate/cofactor complexes Factor A:beta tubulin or Factor D:beta tubulin. TBCD is involved in the tubulin-folding pathway, acting as a GTPase activating protein (GAP) for beta-tubulin. The ADP-ribosylation factor-like protein 2 (ARL2) is able to down-regulate TBCD specifically, thus preventing microtuble disruption (Bhamidipati et al. 2000, Tian et al. 2010).

Literature References
PubMed ID Title Journal Year
20740604 Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity

Tian, G, Thomas, S, Cowan, NJ

Cytoskeleton (Hoboken) 2010
10831612 ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin

Bhamidipati, A, Lewis, SA, Cowan, NJ

J. Cell Biol. 2000
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